激素Resistin是联系肥胖症与糖尿病的关键
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2001年1月18日
NEW YORK (Reuters Health) - A team of US researchers has identified a hormone that may explain why obese people are more prone to type 2 diabetes.
Their study in mice found that fat cells produce a hormone that blocks the action of insulin--the hormone that regulates blood glucose (sugar). When levels of sugar in the blood are high (after a meal, for example) insulin levels rise and deposit sugar into cells throughout the body.
People with diabetes tend to have high blood sugar, a condition that can cause kidney disease, nerve damage and stroke, because they have become resistant to insulin.
, 百拇医药
The hormone, named resistin after the mechanism by which it is thought to lead to diabetes, could provide doctors with a way to identify and treat people with very early symptoms of the disease, according to lead author Dr. Mitchell A. Lazar.
``Measurement of elevated resistin levels might be a way to detect type 2 diabetes earlier than is currently possible,'' said Lazar, director of the Penn Diabetes Center at the University of Pennsylvania School of Medicine.
, 百拇医药
``Moreover, if high levels of resistin in the blood contribute to diabetes, as our data suggest, then blocking resistin would be an exciting new approach to the treatment of diabetes,'' Lazar told Reuters Health.
The researchers have identified the hormone in humans and plan to study how levels vary in obese and diabetic people, he explained.
But Dr. Jeffrey S. Flier, from Beth Israel Deaconess Medical Center in Boston, Massachusetts, cautions that the discovery of resistin is only a first step. Finding a way to use the hormone in the treatment of diabetes could take ``quite a few years,'' Flier told Reuters Health.
, 百拇医药
``We must find out how and where in the body resistin acts to cause insulin resistance,'' said Flier, who wrote an editorial that accompanies the study in the January 18th issue of Nature. ''In humans, we will only know its exact role after antagonists to it have been developed and given to people.''
In mice, levels of resistin rose in tandem with body weight and insulin resistance. Healthy mice that received resistin injections became less responsive to insulin and their blood sugar rose, study findings show.
, 百拇医药
``These data suggest that resistin is a unique hormone whose effects on glucose metabolism are antagonistic to those of insulin,'' Lazar's team concludes.
According to Lazar, the hormone makes sense from the point of view of evolution, as it would allow people and species to survive times of famine. But while storing fat may have been an advantage when food was scarce and people had to burn calories in order to eat, it can be harmful in modern times, when high-calorie, high-fat food is ubiquitous and people need only to drive their car to the local supermarket for a dizzying choice of these foods.
, 百拇医药
``These changes in lifestyle and diet have occurred much too rapidly to be dealt with evolutionarily. What was once efficiency has led to obesity,'' Lazar said.
According to a recent estimate by the Centers for Disease Control and Prevention (news - web sites) (CDC), a 60% rise in obesity during the 1990s helped fuel a 33% increase in type 2 diabetes in America.
Type 2 diabetes accounts for about 90% of the more than 16 million cases of diabetes in the US, the American Diabetes Association estimates.
The researchers stumbled upon the hormone while investigating the mechanism of a class of anti-diabetes drugs known as thiazolidinediones, which sensitize the body to insulin.
SOURCE: Nature 2001;409:292-293, 307-312., 百拇医药
Their study in mice found that fat cells produce a hormone that blocks the action of insulin--the hormone that regulates blood glucose (sugar). When levels of sugar in the blood are high (after a meal, for example) insulin levels rise and deposit sugar into cells throughout the body.
People with diabetes tend to have high blood sugar, a condition that can cause kidney disease, nerve damage and stroke, because they have become resistant to insulin.
, 百拇医药
The hormone, named resistin after the mechanism by which it is thought to lead to diabetes, could provide doctors with a way to identify and treat people with very early symptoms of the disease, according to lead author Dr. Mitchell A. Lazar.
``Measurement of elevated resistin levels might be a way to detect type 2 diabetes earlier than is currently possible,'' said Lazar, director of the Penn Diabetes Center at the University of Pennsylvania School of Medicine.
, 百拇医药
``Moreover, if high levels of resistin in the blood contribute to diabetes, as our data suggest, then blocking resistin would be an exciting new approach to the treatment of diabetes,'' Lazar told Reuters Health.
The researchers have identified the hormone in humans and plan to study how levels vary in obese and diabetic people, he explained.
But Dr. Jeffrey S. Flier, from Beth Israel Deaconess Medical Center in Boston, Massachusetts, cautions that the discovery of resistin is only a first step. Finding a way to use the hormone in the treatment of diabetes could take ``quite a few years,'' Flier told Reuters Health.
, 百拇医药
``We must find out how and where in the body resistin acts to cause insulin resistance,'' said Flier, who wrote an editorial that accompanies the study in the January 18th issue of Nature. ''In humans, we will only know its exact role after antagonists to it have been developed and given to people.''
In mice, levels of resistin rose in tandem with body weight and insulin resistance. Healthy mice that received resistin injections became less responsive to insulin and their blood sugar rose, study findings show.
, 百拇医药
``These data suggest that resistin is a unique hormone whose effects on glucose metabolism are antagonistic to those of insulin,'' Lazar's team concludes.
According to Lazar, the hormone makes sense from the point of view of evolution, as it would allow people and species to survive times of famine. But while storing fat may have been an advantage when food was scarce and people had to burn calories in order to eat, it can be harmful in modern times, when high-calorie, high-fat food is ubiquitous and people need only to drive their car to the local supermarket for a dizzying choice of these foods.
, 百拇医药
``These changes in lifestyle and diet have occurred much too rapidly to be dealt with evolutionarily. What was once efficiency has led to obesity,'' Lazar said.
According to a recent estimate by the Centers for Disease Control and Prevention (news - web sites) (CDC), a 60% rise in obesity during the 1990s helped fuel a 33% increase in type 2 diabetes in America.
Type 2 diabetes accounts for about 90% of the more than 16 million cases of diabetes in the US, the American Diabetes Association estimates.
The researchers stumbled upon the hormone while investigating the mechanism of a class of anti-diabetes drugs known as thiazolidinediones, which sensitize the body to insulin.
SOURCE: Nature 2001;409:292-293, 307-312., 百拇医药