Pet研究结果预测与神经退行性疾病有关的进一步认知功能下降
WESTPORT, CT (Reuters Health) - Positron emission tomography (PET) scanning can identify those patients presenting with cognitive decline who are likely to develop Alzheimer's disease or other neurodegenerative diseases over the next 3 years, according to an international consortium of investigators.
Dr. Daniel H. S. Silverman, of the University of California, Los Angeles School of Medicine, and associates conducted imaging studies on 284 patients between 1984 and 2000. As reported in The Journal of the American Medical Association for November 7, cognitive problems were reported by 97% of subjects, who were considered to be "mildly impaired."
, http://www.100md.com
"When a patient presents with cognitive or behavioral symptoms due to a progressive neurodegenerative process, sufficient cortical degeneration has usually already occurred to detectably diminish metabolism of some areas of the cortex," the investigators write.
Among 146 patients who underwent longitudinal followup for an average of 3.2 years after scanning, 59% experienced progressive cognitive decline. Based on baseline regional brain metabolism criteria "established a priori," PET scans identified progressive neurodegenerative disease in this group with a sensitivity and specificity of 91% and 75%, respectively.
, 百拇医药
A further 138 patients were examined postmortem an average of 2.9 years after PET. In this situation, sensitivity and specificity were 94% and 73%.
"While it's not a perfect discriminator, [PET] does a pretty accurate job of discriminating between" Alzheimer's disease and other degenerative disorders, Dr. Silverman told Reuters Health. "Not only do you find areas of decreased metabolism, but different neurodegenerative diseases have different places where that characteristically happens," he explained. "The sensitivity was the same in both cases, and specificity just 5% less for Alzheimer's disease specifically."
, http://www.100md.com
Dr. Silverman recommends that an appropriate workup be performed for patients presenting with memory problems before PET scanning is conducted. This would include a good history and physical, including a neurological examination, as well as laboratory tests and perhaps computed tomography or magnetic resonance imaging.
"Anything that can be treated should be treated," he said. "Sometimes, though, patients have more than one thing. It's not uncommon for physicians to treat the patient for depression. If the patient doesn't have a complete reversal of the symptoms, then he or she should have a PET scan.
JAMA 2001;286:2120-2127.
-Westport Newsroom 203 319 2700, 百拇医药
Dr. Daniel H. S. Silverman, of the University of California, Los Angeles School of Medicine, and associates conducted imaging studies on 284 patients between 1984 and 2000. As reported in The Journal of the American Medical Association for November 7, cognitive problems were reported by 97% of subjects, who were considered to be "mildly impaired."
, http://www.100md.com
"When a patient presents with cognitive or behavioral symptoms due to a progressive neurodegenerative process, sufficient cortical degeneration has usually already occurred to detectably diminish metabolism of some areas of the cortex," the investigators write.
Among 146 patients who underwent longitudinal followup for an average of 3.2 years after scanning, 59% experienced progressive cognitive decline. Based on baseline regional brain metabolism criteria "established a priori," PET scans identified progressive neurodegenerative disease in this group with a sensitivity and specificity of 91% and 75%, respectively.
, 百拇医药
A further 138 patients were examined postmortem an average of 2.9 years after PET. In this situation, sensitivity and specificity were 94% and 73%.
"While it's not a perfect discriminator, [PET] does a pretty accurate job of discriminating between" Alzheimer's disease and other degenerative disorders, Dr. Silverman told Reuters Health. "Not only do you find areas of decreased metabolism, but different neurodegenerative diseases have different places where that characteristically happens," he explained. "The sensitivity was the same in both cases, and specificity just 5% less for Alzheimer's disease specifically."
, http://www.100md.com
Dr. Silverman recommends that an appropriate workup be performed for patients presenting with memory problems before PET scanning is conducted. This would include a good history and physical, including a neurological examination, as well as laboratory tests and perhaps computed tomography or magnetic resonance imaging.
"Anything that can be treated should be treated," he said. "Sometimes, though, patients have more than one thing. It's not uncommon for physicians to treat the patient for depression. If the patient doesn't have a complete reversal of the symptoms, then he or she should have a PET scan.
JAMA 2001;286:2120-2127.
-Westport Newsroom 203 319 2700, 百拇医药