“问题少女”体内应激性激素少
http://www.100md.com
2001年4月16日
路透社纽约健康消息 一项新的研究发现，有好斗、逃学等不良行为的“问题少女”，其应激性激素皮质醇的水平要比其同龄人为低。
该项研究由美国宾夕法尼亚州匹兹堡大学医学院的凯思琳·芭爵博士领导，首次对行为异常少女的皮质醇水平进行了研究。皮质醇是由肾上腺分泌的应激性激素，当遇到意外刺激时，人或动物是“战斗或逃跑”？皮质醇是左右其决定的元素之一。以往的研究已显示有暴力倾向男性的皮质醇水平比非暴力男性为低，从而引发研究者研究：该激素是否也是导致少女行为异常的一个因素。
芭爵的研究小组把47位行为异常的少女与一组37位行为正常的少女进行了比较，前者血中的皮质醇水平明显低于后者。研究发现，在青春期少女当中，行为异常是一个普遍的问题，在15至17岁的少女当中受影响的比例比例高达十分之一，这一系列行为问题包括破坏性及好斗行为、说谎、偷窃等，行为异常给少女本人及社会都带来危害。
根据美国国家精神卫生研究所的报告，大多数有行为异常的儿童或青少年可能因身处某些事件及情景而起异常反应，需要更多的研究以明确是否生物因素是导致行为异常的一个因素。
, http://www.100md.com
研究者指出，为了找出低皮质醇水平与行为异常两者何者为因、何者为果，需要预先在孩子幼年时检测其皮质醇水平，然后随着孩子的长大对其皮质醇水平进行追踪。研究还发现，低水平的皮质醇不仅与行为异常有关，而且在一些有精神创伤者及有自体免疫失调的病人身上也发现这种情况。
来源：综合精神病学档案2001;58:297-302.
Stress Hormone Linked to Girls‘ Behavior Problems
NEW YORK (Reuters Health) - Teenage girls who have behavioral problems--such as acting aggressive and skipping school--have lower levels of the stress hormone cortisol than their peers, a new study has found.
, 百拇医药
The study, published in the March issue of Archives of General Psychiatry, is the first to look at levels of cortisol in girls with conduct disorder, a set of behavioral problems including destructive and aggressive behavior, acting out, and lying and stealing.
However, lead author Dr. Kathleen Pajer of the University of Pittsburgh School of Medicine in Pennsylvania told Reuters Health the study does not show whether low levels of cortisol are a cause or a result of conduct disorder, and it also does not point toward treatment strategies for the condition.
, 百拇医药
Cortisol is a stress hormone released by the adrenal glands as part of the ``fight or flight‘‘ response, Pajer explained. Past studies have shown that violent males have lower cortisol levels than nonviolent males, leading the researchers to investigate the hormone as a factor in conduct disorder in girls.
Conduct disorder is common among adolescent girls, affecting as many as 1 in 10 girls aged 15 to 17, Pajer and her colleagues note. The disorder carries risks for the girls themselves and for society.
, 百拇医药
According to the National Institute of Mental Health, ``most children or adolescents with conduct disorder are probably reacting to events and situations in their lives. More research is needed to determine if biology is a factor in conduct disorder.‘‘
Pajer‘s team compared 47 teenage girls with conduct disorder to a group of 37 teens without the disorder. The girls with conduct disorder had significantly lower cortisol levels in their blood than the other girls did, the report indicates.
, http://www.100md.com
To find out whether low cortisol levels cause conduct disorder or vice versa, ``you would need to do a prospective study examining cortisol levels in infancy and then follow the kids,‘‘ Pajer told Reuters Health.
``Low cortisol is not only associated with conduct disorder, but is found in some people who have been traumatized and in patients with some autoimmune disorders,‘‘ she added.
SOURCE: Archives of General Psychiatry 2001;58:297-302., http://www.100md.com
该项研究由美国宾夕法尼亚州匹兹堡大学医学院的凯思琳·芭爵博士领导，首次对行为异常少女的皮质醇水平进行了研究。皮质醇是由肾上腺分泌的应激性激素，当遇到意外刺激时，人或动物是“战斗或逃跑”？皮质醇是左右其决定的元素之一。以往的研究已显示有暴力倾向男性的皮质醇水平比非暴力男性为低，从而引发研究者研究：该激素是否也是导致少女行为异常的一个因素。
芭爵的研究小组把47位行为异常的少女与一组37位行为正常的少女进行了比较，前者血中的皮质醇水平明显低于后者。研究发现，在青春期少女当中，行为异常是一个普遍的问题，在15至17岁的少女当中受影响的比例比例高达十分之一，这一系列行为问题包括破坏性及好斗行为、说谎、偷窃等，行为异常给少女本人及社会都带来危害。
根据美国国家精神卫生研究所的报告，大多数有行为异常的儿童或青少年可能因身处某些事件及情景而起异常反应，需要更多的研究以明确是否生物因素是导致行为异常的一个因素。
, http://www.100md.com
研究者指出，为了找出低皮质醇水平与行为异常两者何者为因、何者为果，需要预先在孩子幼年时检测其皮质醇水平，然后随着孩子的长大对其皮质醇水平进行追踪。研究还发现，低水平的皮质醇不仅与行为异常有关，而且在一些有精神创伤者及有自体免疫失调的病人身上也发现这种情况。
来源：综合精神病学档案2001;58:297-302.
Stress Hormone Linked to Girls‘ Behavior Problems
NEW YORK (Reuters Health) - Teenage girls who have behavioral problems--such as acting aggressive and skipping school--have lower levels of the stress hormone cortisol than their peers, a new study has found.
, 百拇医药
The study, published in the March issue of Archives of General Psychiatry, is the first to look at levels of cortisol in girls with conduct disorder, a set of behavioral problems including destructive and aggressive behavior, acting out, and lying and stealing.
However, lead author Dr. Kathleen Pajer of the University of Pittsburgh School of Medicine in Pennsylvania told Reuters Health the study does not show whether low levels of cortisol are a cause or a result of conduct disorder, and it also does not point toward treatment strategies for the condition.
, 百拇医药
Cortisol is a stress hormone released by the adrenal glands as part of the ``fight or flight‘‘ response, Pajer explained. Past studies have shown that violent males have lower cortisol levels than nonviolent males, leading the researchers to investigate the hormone as a factor in conduct disorder in girls.
Conduct disorder is common among adolescent girls, affecting as many as 1 in 10 girls aged 15 to 17, Pajer and her colleagues note. The disorder carries risks for the girls themselves and for society.
, 百拇医药
According to the National Institute of Mental Health, ``most children or adolescents with conduct disorder are probably reacting to events and situations in their lives. More research is needed to determine if biology is a factor in conduct disorder.‘‘
Pajer‘s team compared 47 teenage girls with conduct disorder to a group of 37 teens without the disorder. The girls with conduct disorder had significantly lower cortisol levels in their blood than the other girls did, the report indicates.
, http://www.100md.com
To find out whether low cortisol levels cause conduct disorder or vice versa, ``you would need to do a prospective study examining cortisol levels in infancy and then follow the kids,‘‘ Pajer told Reuters Health.
``Low cortisol is not only associated with conduct disorder, but is found in some people who have been traumatized and in patients with some autoimmune disorders,‘‘ she added.
SOURCE: Archives of General Psychiatry 2001;58:297-302., http://www.100md.com