酒渣鼻发生与面部皮肤温度较高有关
路透社纽约健康消息 最近的研究结果表明，酒渣鼻患者不仅出现面部疖肿及丘疹，而且面部皮肤的温度也要比正常人要高。
根据美国酒渣鼻研究会的报告，酒渣鼻是一种常见的皮肤病，约有1千4百万美国人患此病。该病的特征是鼻和面颊发红，特别是在从事体力活动期间及之后出现，并且出现鼻子肿大、皮肤毛细血管扩张。
亚利桑那州斯哥带尔梅奥诊所的马克·达赫尔博士指出，因为口服及局部抗菌素治疗酒渣鼻有效果，研究人员一直考虑酒渣鼻的炎症、疖肿和丘疹是否与细菌有关。达赫尔博士的研究发现，温度可以改变许多常见细菌的毒性，从而为常见但了解甚少的酒渣鼻研究开辟了一条全新的研究途径。
达赫尔及其同事在实验中分别从未经治疗的酒渣鼻患者的丘疹处以及从正常人的皮肤里收集细菌，分为两组存储在华氏86度和华氏98.6度的环境中。结果表明：在上述两种温度环境中细菌的生长率是相似的。然而，来自酒渣鼻病人的细菌都能释放脂肪酶，而且分泌量在华氏98.6度环境中更为多。相比之下，正常人的细菌样品中仅仅有半数能分泌脂肪酶；研究人员提到，脂肪酶的产生通常发生在细菌消耗了后，这点可以解释为何酒渣鼻伴有皮肤干燥。
, 百拇医药
研究合作者、来自明尼阿波利斯的明尼苏达医学院的帕特里克· M ·斯克赫利弗特博士补充说：存储在华氏98.6度的细菌还释放数种未曾命名的蛋白质。他和同事认为，在较高皮肤温度下发生的这类的异常变化可以导致酒渣鼻的面部肿块和丘疹。研究结果在近期在华盛顿举行的皮肤病研究会会议上宣读。
然而，南加利福尼亚大学医学院的大卫·沃伦博士却发表了不同意见，他认为：酒渣鼻患者的皮肤温度不一定都比正常皮肤温度高；并未见到任何已发表的研究报告证明这点。沃伦博士与达赫尔研究组并无研究上的合作。他强调，华氏98.6度是正常体温，并且正常皮肤和酒渣鼻皮肤之间温度不会相差7度。然而，沃伦博士承认，酒渣鼻皮肤比正常皮肤温度要高是合乎逻辑的，正如潮红的皮肤比正常皮肤温度要高一些一样。但是，他补充说，“我们不知道这种温差的程度以及那些差别是否会改变细菌的活性。”
Skin Disorder Rosacea Linked to Facial Warmth
, http://www.100md.com
NEW YORK (Reuters Health) - In addition to facial bumps and pimples, individuals who suffer with rosacea may also have higher facial temperatures than those without the skin disorder, researchers report. And recent study findings suggest that the two phenomena may be linked.
Rosacea is a common skin condition that affects an estimated 14 million Americans, according to the National Rosacea Society. It is characterized by redness over the nose and cheeks, especially during and after periods of physical exertion, as well as symptoms including a swollen nose, and telangiectasia--small, dilated blood vessels in the skin.
, http://www.100md.com
``Researchers have long wondered whether bacteria may be responsible for the inflammation, bumps and pimples of rosacea, especially because they can be successfully treated with oral and topical antibiotics,‘‘ Dr. Mark Dahl, of the Mayo Clinic, in Scottsdale, Arizona, said in a statement.
``Our findings suggest that temperature may change the toxicity of many types of common bacteria, opening a whole new avenue of research into this widespread but poorly understood disorder,‘‘ he added.
, 百拇医药
The study findings were presented during the recent meeting of the Society for Investigative Dermatology, in Washington.
Dahl and his colleagues experimented with bacteria obtained from the pimples of individuals with untreated rosacea. Bacteria from individuals without rosacea were used for comparison. All of the bacteria were stored at both 86 degrees and 98.6 degrees Fahrenheit.
Findings show that the bacteria exhibited identical growth rates in the two temperatures. However, all of the bacteria from the rosacea patients released the enzyme lipase, and more lipase was secreted at 98.6 degrees than at 86 degrees. In contrast, only half of the bacteria samples from individuals without rosacea secreted lipase.
, 百拇医药
Lipase production usually occurred as the bacteria were being depleted of nutrients, which may explain the dryness associated with rosacea, the researchers note.
In addition, the bacteria stored at 98.6 degrees also released several unidentified proteins, study co-author Dr. Patrick M. Schlievert, of the University of Minnesota Medical School, in Minneapolis, told Reuters Health. Such abnormal activities occurring at the higher temperature may trigger the facial bumps and pimples associated with rosacea, he and his colleagues suggest.
, http://www.100md.com
However, the temperature of rosacea skin is not necessarily warmer than that of normal skin, according to Dr. David Voron, of the University of Southern California School of Medicine. ``I am not aware of any published studies proving that,‘‘ he told Reuters Health in an interview. Voron is not connected with Dahl‘s research.
He noted that 98.6 degrees is ``normal body temperature...and there‘s not a 7-degree difference between normal skin and rosacea skin.‘‘
Voron did acknowledge, however, that it would be logical for rosacea skin to be warmer than normal skin--just as red, sunburned skin is warmer than normal skin.
But, he added, ``we don‘t know the extent of the difference and whether that difference would change the activity of the bacteria.‘‘, 百拇医药
根据美国酒渣鼻研究会的报告，酒渣鼻是一种常见的皮肤病，约有1千4百万美国人患此病。该病的特征是鼻和面颊发红，特别是在从事体力活动期间及之后出现，并且出现鼻子肿大、皮肤毛细血管扩张。
亚利桑那州斯哥带尔梅奥诊所的马克·达赫尔博士指出，因为口服及局部抗菌素治疗酒渣鼻有效果，研究人员一直考虑酒渣鼻的炎症、疖肿和丘疹是否与细菌有关。达赫尔博士的研究发现，温度可以改变许多常见细菌的毒性，从而为常见但了解甚少的酒渣鼻研究开辟了一条全新的研究途径。
达赫尔及其同事在实验中分别从未经治疗的酒渣鼻患者的丘疹处以及从正常人的皮肤里收集细菌，分为两组存储在华氏86度和华氏98.6度的环境中。结果表明：在上述两种温度环境中细菌的生长率是相似的。然而，来自酒渣鼻病人的细菌都能释放脂肪酶，而且分泌量在华氏98.6度环境中更为多。相比之下，正常人的细菌样品中仅仅有半数能分泌脂肪酶；研究人员提到，脂肪酶的产生通常发生在细菌消耗了后，这点可以解释为何酒渣鼻伴有皮肤干燥。
, 百拇医药
研究合作者、来自明尼阿波利斯的明尼苏达医学院的帕特里克· M ·斯克赫利弗特博士补充说：存储在华氏98.6度的细菌还释放数种未曾命名的蛋白质。他和同事认为，在较高皮肤温度下发生的这类的异常变化可以导致酒渣鼻的面部肿块和丘疹。研究结果在近期在华盛顿举行的皮肤病研究会会议上宣读。
然而，南加利福尼亚大学医学院的大卫·沃伦博士却发表了不同意见，他认为：酒渣鼻患者的皮肤温度不一定都比正常皮肤温度高；并未见到任何已发表的研究报告证明这点。沃伦博士与达赫尔研究组并无研究上的合作。他强调，华氏98.6度是正常体温，并且正常皮肤和酒渣鼻皮肤之间温度不会相差7度。然而，沃伦博士承认，酒渣鼻皮肤比正常皮肤温度要高是合乎逻辑的，正如潮红的皮肤比正常皮肤温度要高一些一样。但是，他补充说，“我们不知道这种温差的程度以及那些差别是否会改变细菌的活性。”
Skin Disorder Rosacea Linked to Facial Warmth
, http://www.100md.com
NEW YORK (Reuters Health) - In addition to facial bumps and pimples, individuals who suffer with rosacea may also have higher facial temperatures than those without the skin disorder, researchers report. And recent study findings suggest that the two phenomena may be linked.
Rosacea is a common skin condition that affects an estimated 14 million Americans, according to the National Rosacea Society. It is characterized by redness over the nose and cheeks, especially during and after periods of physical exertion, as well as symptoms including a swollen nose, and telangiectasia--small, dilated blood vessels in the skin.
, http://www.100md.com
``Researchers have long wondered whether bacteria may be responsible for the inflammation, bumps and pimples of rosacea, especially because they can be successfully treated with oral and topical antibiotics,‘‘ Dr. Mark Dahl, of the Mayo Clinic, in Scottsdale, Arizona, said in a statement.
``Our findings suggest that temperature may change the toxicity of many types of common bacteria, opening a whole new avenue of research into this widespread but poorly understood disorder,‘‘ he added.
, 百拇医药
The study findings were presented during the recent meeting of the Society for Investigative Dermatology, in Washington.
Dahl and his colleagues experimented with bacteria obtained from the pimples of individuals with untreated rosacea. Bacteria from individuals without rosacea were used for comparison. All of the bacteria were stored at both 86 degrees and 98.6 degrees Fahrenheit.
Findings show that the bacteria exhibited identical growth rates in the two temperatures. However, all of the bacteria from the rosacea patients released the enzyme lipase, and more lipase was secreted at 98.6 degrees than at 86 degrees. In contrast, only half of the bacteria samples from individuals without rosacea secreted lipase.
, 百拇医药
Lipase production usually occurred as the bacteria were being depleted of nutrients, which may explain the dryness associated with rosacea, the researchers note.
In addition, the bacteria stored at 98.6 degrees also released several unidentified proteins, study co-author Dr. Patrick M. Schlievert, of the University of Minnesota Medical School, in Minneapolis, told Reuters Health. Such abnormal activities occurring at the higher temperature may trigger the facial bumps and pimples associated with rosacea, he and his colleagues suggest.
, http://www.100md.com
However, the temperature of rosacea skin is not necessarily warmer than that of normal skin, according to Dr. David Voron, of the University of Southern California School of Medicine. ``I am not aware of any published studies proving that,‘‘ he told Reuters Health in an interview. Voron is not connected with Dahl‘s research.
He noted that 98.6 degrees is ``normal body temperature...and there‘s not a 7-degree difference between normal skin and rosacea skin.‘‘
Voron did acknowledge, however, that it would be logical for rosacea skin to be warmer than normal skin--just as red, sunburned skin is warmer than normal skin.
But, he added, ``we don‘t know the extent of the difference and whether that difference would change the activity of the bacteria.‘‘, 百拇医药