饮食疗法治克罗恩氏病看好
路透社纽约健康消息 在英国进行的一项小型研究结果表明，不含微粒体的膳食可以治疗克罗恩氏病(Crohn‘s病)。而存在于食物中的无论是天然的还是人工添加的微粒，都有可能加重克罗恩氏病的炎症。
克罗恩氏病是一种以腹痛、腹泻为主要特征的炎症性肠病，小肠炎症可以引起营养吸收不良等并发症。研究人员认为，克罗恩氏病的病因与遗传有一定的关系，但目前该病的病因尚未完全明确。治疗方法包括应用皮质类固醇等药物缓解肠道炎症，或者用外科手术治疗，切除病变的肠道。目前仍没有一种膳食能对克罗恩氏病有效的。
早期的研究在肠细胞中发现了一些微粒，主要是二氧化钛及铝矽酸盐。其中二氧化钛是冰糖和其他糖果、乳酪、沙司、牙膏及许多药物中的增白剂，而铝矽酸盐能避免结块，因此常用在粉末状食品中。
在这项针对20名克罗恩氏病患者的研究中，研究人员订制了一种不含这些微粒的食谱，去除了熟食、加工过的肉类鱼类和奶酪，速食面等。参加实验的病人除了采用这种食谱外，还进食经过洗、削、剥去除土壤残留物的新鲜水果蔬菜，而且还禁服非处方药，因为许多在药房能买到的非处方药都含有二氧化钛。实验组和对照组的病人都不进食高纤维的水果和蔬菜、全谷类面粉及谷类、坚果等，因为低纤维膳食对克罗恩氏病患者是有益的。
, 百拇医药
结果发现半数的病人在进食低微粒膳食四个月后，症状有了明显的改善。据发表在二月份的《欧洲胃肠及肝脏病学》杂志上的研究报告，这种膳食不含人工食品，可以减轻小肠的炎症性症状。
美国俄亥俄州的克里夫兰临床医学基金会的布莱特拉施那博士认为，微粒理论是针对饮食如何会恶化克罗恩氏病的一项新奇且独特的假设。但他并不认为患克罗恩氏病患者应该采取此种疗法。因为克罗恩氏病复杂，饮食推荐工作要具体情况具体分析。
来源：《欧洲肠胃病学和肝脏病学杂志》2001;13:101
Diet Shows Promise Against Crohn‘s Disease
NEW YORK (Reuters Health) - A special diet that excludes certain ``ultrafine‘‘ particles found in some foods may fight the intestinal disorder Crohn‘s disease, according to results from a small study in the UK.
, 百拇医药
In a study of 20 Crohn‘s disease patients, researchers found that the half who were put on a ``low-microparticle‘‘ diet experienced a significant improvement in their symptoms over 4 months. The diet, which prohibits many processed foods, may help by reducing inflammation in the small intestine, according to a report in the February issue of the European Journal of Gastroenterology and Hepatology.
Crohn‘s is an inflammatory bowel disease marked by abdominal pain and diarrhea. Inflammation in the small intestine can also lead to complications such as poor absorption of nutrients. While researchers believe genetic factors are involved in the development of Crohn‘s, the exact cause remains unknown.
, http://www.100md.com
Treatment may include drugs such corticosteroids, which ease the bowel inflammation, or surgery to remove the part of the intestine affected by the disease. No single diet has proven effective against Crohn‘s.
In the current study, Dr. Jonathan J. Powell and his colleagues at St. Thomas‘ Hospital in London tested the theory that ``undegradable‘‘ microparticles that get into foods either naturally or through additives might worsen the inflammation seen in Crohn‘s.
, 百拇医药
In earlier research, the investigators found such particles--mainly titanium dioxide and aluminosilicates--in intestinal cells. Titanium dioxide is a ``whitening‘‘ agent used in candy and other confections, some cheeses and sauces, toothpaste and many medications. Aluminosilicates prevent caking and are therefore often used in granular and powdered food products, according to the report.
So Powell‘s team developed a diet that excluded these types of products: gone were ready-made meals, processed meats, fish and cheese, and instant noodle products. Study patients who followed the diet also peeled and washed fresh fruits and vegetables to cut down on soil residue. And they avoided over-the-counter drugs, which often contain titanium dioxide.
, 百拇医药
Both study groups avoided high-fiber fruits and vegetables, whole-grain flours and cereals with fruit or nuts. Low-fiber diets have been shown to help some Crohn‘s patients.
After 4 months, Powell‘s team found that seven of the nine patients on the diet were in remission, compared with none of those in the other group.
A Crohn‘s expert not involved in the study called the results ‘‘interesting and important.‘‘
, http://www.100md.com
Dr. Bret Lashner of the Cleveland Clinic Foundation in Ohio told Reuters Health that the microparticle theory is a ``novel and unique hypothesis‘‘ on how diet can worsen Crohn‘s symptoms. Moreover, he said, ``this is not a fad diet. It has reasonable restrictions.‘‘
Still, Lashner said, ``I don‘t think people with Crohn‘s should run out and try this.‘‘
The disease is complex, Lashner explained, and dietary recommendations need to be individualized.
SOURCE: European Journal of Gastroenterology and Hepatology 2001;13:101-, 百拇医药
克罗恩氏病是一种以腹痛、腹泻为主要特征的炎症性肠病，小肠炎症可以引起营养吸收不良等并发症。研究人员认为，克罗恩氏病的病因与遗传有一定的关系，但目前该病的病因尚未完全明确。治疗方法包括应用皮质类固醇等药物缓解肠道炎症，或者用外科手术治疗，切除病变的肠道。目前仍没有一种膳食能对克罗恩氏病有效的。
早期的研究在肠细胞中发现了一些微粒，主要是二氧化钛及铝矽酸盐。其中二氧化钛是冰糖和其他糖果、乳酪、沙司、牙膏及许多药物中的增白剂，而铝矽酸盐能避免结块，因此常用在粉末状食品中。
在这项针对20名克罗恩氏病患者的研究中，研究人员订制了一种不含这些微粒的食谱，去除了熟食、加工过的肉类鱼类和奶酪，速食面等。参加实验的病人除了采用这种食谱外，还进食经过洗、削、剥去除土壤残留物的新鲜水果蔬菜，而且还禁服非处方药，因为许多在药房能买到的非处方药都含有二氧化钛。实验组和对照组的病人都不进食高纤维的水果和蔬菜、全谷类面粉及谷类、坚果等，因为低纤维膳食对克罗恩氏病患者是有益的。
, 百拇医药
结果发现半数的病人在进食低微粒膳食四个月后，症状有了明显的改善。据发表在二月份的《欧洲胃肠及肝脏病学》杂志上的研究报告，这种膳食不含人工食品，可以减轻小肠的炎症性症状。
美国俄亥俄州的克里夫兰临床医学基金会的布莱特拉施那博士认为，微粒理论是针对饮食如何会恶化克罗恩氏病的一项新奇且独特的假设。但他并不认为患克罗恩氏病患者应该采取此种疗法。因为克罗恩氏病复杂，饮食推荐工作要具体情况具体分析。
来源：《欧洲肠胃病学和肝脏病学杂志》2001;13:101
Diet Shows Promise Against Crohn‘s Disease
NEW YORK (Reuters Health) - A special diet that excludes certain ``ultrafine‘‘ particles found in some foods may fight the intestinal disorder Crohn‘s disease, according to results from a small study in the UK.
, 百拇医药
In a study of 20 Crohn‘s disease patients, researchers found that the half who were put on a ``low-microparticle‘‘ diet experienced a significant improvement in their symptoms over 4 months. The diet, which prohibits many processed foods, may help by reducing inflammation in the small intestine, according to a report in the February issue of the European Journal of Gastroenterology and Hepatology.
Crohn‘s is an inflammatory bowel disease marked by abdominal pain and diarrhea. Inflammation in the small intestine can also lead to complications such as poor absorption of nutrients. While researchers believe genetic factors are involved in the development of Crohn‘s, the exact cause remains unknown.
, http://www.100md.com
Treatment may include drugs such corticosteroids, which ease the bowel inflammation, or surgery to remove the part of the intestine affected by the disease. No single diet has proven effective against Crohn‘s.
In the current study, Dr. Jonathan J. Powell and his colleagues at St. Thomas‘ Hospital in London tested the theory that ``undegradable‘‘ microparticles that get into foods either naturally or through additives might worsen the inflammation seen in Crohn‘s.
, 百拇医药
In earlier research, the investigators found such particles--mainly titanium dioxide and aluminosilicates--in intestinal cells. Titanium dioxide is a ``whitening‘‘ agent used in candy and other confections, some cheeses and sauces, toothpaste and many medications. Aluminosilicates prevent caking and are therefore often used in granular and powdered food products, according to the report.
So Powell‘s team developed a diet that excluded these types of products: gone were ready-made meals, processed meats, fish and cheese, and instant noodle products. Study patients who followed the diet also peeled and washed fresh fruits and vegetables to cut down on soil residue. And they avoided over-the-counter drugs, which often contain titanium dioxide.
, 百拇医药
Both study groups avoided high-fiber fruits and vegetables, whole-grain flours and cereals with fruit or nuts. Low-fiber diets have been shown to help some Crohn‘s patients.
After 4 months, Powell‘s team found that seven of the nine patients on the diet were in remission, compared with none of those in the other group.
A Crohn‘s expert not involved in the study called the results ‘‘interesting and important.‘‘
, http://www.100md.com
Dr. Bret Lashner of the Cleveland Clinic Foundation in Ohio told Reuters Health that the microparticle theory is a ``novel and unique hypothesis‘‘ on how diet can worsen Crohn‘s symptoms. Moreover, he said, ``this is not a fad diet. It has reasonable restrictions.‘‘
Still, Lashner said, ``I don‘t think people with Crohn‘s should run out and try this.‘‘
The disease is complex, Lashner explained, and dietary recommendations need to be individualized.
SOURCE: European Journal of Gastroenterology and Hepatology 2001;13:101-, 百拇医药