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Alcoholic beverages may spell trouble for asthmatics according to a recent study by Australian researchers published in the March 2000 Journal of Allergy and Clinical Immunology (JACI). The JACI is the peer-reviewed, scientific journal of the American Academy of Allergy, Asthma and Immunology.
Prior research on food-induced asthma has demonstrated a link between alcoholic beverages and asthmatic reactions. In this study, researchers surveyed 366 asthmatics with a self-administered food allergy questionnaire that assessed alcoholic drink-induced asthma in detail. Results showed that 156 (42.6 percent) respondents reported allergic or allergic-like reactions to alcoholic drinks, including cough, blocked nose, itching, facial swelling and hives. One hundred twenty-one (33.1 percent) respondents reported asthmatic responses to alcoholic beverages, with 97 of them indicating that asthma was the main adverse symptom experienced. Asthmatic reactions were generally rapid in onset and moderate in severity.
, 百拇医药
Wine was the most frequent cause of asthmatic reactions, with 139 (37.7 percent) people experiencing reactions to it. One hundred nine (29.8 percent) respondents reported reactions to red wine, 95 (26.0 percent) reported reactions to white wine and 46 (12.6 percent) reported reactions to champagne. Fortified wines, like sherry or port, caused reactions in 42 (11.5 percent) individuals, beer in 46 (12.6 percent) individuals, and spirits, like brandy, whisky and vodka, in 21 (5.7 percent) individuals.
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The mechanisms underlying wine-induced reactions are not known. Sulfite additives have been associated with triggering asthmatic responses. They are present in significant levels in most wines, but other ingredients in wine can also trigger an asthmatic response.
No significant difference was found between alcoholic drink-sensitive asthmatic subjects and asthmatic subjects not sensitive to these drinks with respect to age, sex, race, asthma severity, oral corticosteroid use or prior positive allergy skin test reactivity.
, http://www.100md.com
Genetic variation may be responsible for serum IgE levels
A variation, or polymorphism, on the interleukin-13 (IL-13) gene was found to be correlated with total serum immunoglobulin-E (IgE) levels in a large group of children in Arizona and Germany in a study by American and German researchers published in the March 2000 JACI. IL-13 is one of a number of cytokines produced by T cells that allow T cells to "communicate" with the rest of the immune system.
, 百拇医药
Researchers studied the DNA of 1,399 children in three populations living in divergent social and geographic conditions. They identified seven genetic polymorphisms present in the gene for IL-13. IL-13 and IL-4 are the only known cytokine signals that can initiate IgE production. IgE is a class of antibodies normally present in low levels in humans but found in larger quantities in people with allergic disease. It is the primary antibody responsible for initiating allergic and asthmatic reactions. Carriers of these seven genetic variants had significantly higher levels of IgE than subjects without the same polymorphisms. The authors concluded that these genetic variants in the IL-13 gene may be very important determinants of total serum levels of IgE., 百拇医药
Prior research on food-induced asthma has demonstrated a link between alcoholic beverages and asthmatic reactions. In this study, researchers surveyed 366 asthmatics with a self-administered food allergy questionnaire that assessed alcoholic drink-induced asthma in detail. Results showed that 156 (42.6 percent) respondents reported allergic or allergic-like reactions to alcoholic drinks, including cough, blocked nose, itching, facial swelling and hives. One hundred twenty-one (33.1 percent) respondents reported asthmatic responses to alcoholic beverages, with 97 of them indicating that asthma was the main adverse symptom experienced. Asthmatic reactions were generally rapid in onset and moderate in severity.
, 百拇医药
Wine was the most frequent cause of asthmatic reactions, with 139 (37.7 percent) people experiencing reactions to it. One hundred nine (29.8 percent) respondents reported reactions to red wine, 95 (26.0 percent) reported reactions to white wine and 46 (12.6 percent) reported reactions to champagne. Fortified wines, like sherry or port, caused reactions in 42 (11.5 percent) individuals, beer in 46 (12.6 percent) individuals, and spirits, like brandy, whisky and vodka, in 21 (5.7 percent) individuals.
, http://www.100md.com
The mechanisms underlying wine-induced reactions are not known. Sulfite additives have been associated with triggering asthmatic responses. They are present in significant levels in most wines, but other ingredients in wine can also trigger an asthmatic response.
No significant difference was found between alcoholic drink-sensitive asthmatic subjects and asthmatic subjects not sensitive to these drinks with respect to age, sex, race, asthma severity, oral corticosteroid use or prior positive allergy skin test reactivity.
, http://www.100md.com
Genetic variation may be responsible for serum IgE levels
A variation, or polymorphism, on the interleukin-13 (IL-13) gene was found to be correlated with total serum immunoglobulin-E (IgE) levels in a large group of children in Arizona and Germany in a study by American and German researchers published in the March 2000 JACI. IL-13 is one of a number of cytokines produced by T cells that allow T cells to "communicate" with the rest of the immune system.
, 百拇医药
Researchers studied the DNA of 1,399 children in three populations living in divergent social and geographic conditions. They identified seven genetic polymorphisms present in the gene for IL-13. IL-13 and IL-4 are the only known cytokine signals that can initiate IgE production. IgE is a class of antibodies normally present in low levels in humans but found in larger quantities in people with allergic disease. It is the primary antibody responsible for initiating allergic and asthmatic reactions. Carriers of these seven genetic variants had significantly higher levels of IgE than subjects without the same polymorphisms. The authors concluded that these genetic variants in the IL-13 gene may be very important determinants of total serum levels of IgE., 百拇医药