乙型肝炎病毒基因型及其临床意义的研究进展
乙型肝炎病毒;基因分型;变异;临床意义,游晶,陈红英,杨海秋,唐宝璋,黄梦玲,庄林,游晶,通讯作者:,AdvancesintheresearchesonhepatitisBvirusgenotypinganditsclinicalsignific
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游晶, 陈红英, 杨海秋, 唐宝璋, 黄梦玲, 昆明医学院第一附属医院感染病科 云南省昆明市 650032
庄林, 昆明市第三人民医院肝病科 云南省昆明市 650041
游晶, 博士, 副教授, 副主任医师, 硕士生导师, 主要从事病毒性肝炎及感染性疾病的基础与临床研究.
通讯作者: 游晶, 650032, 云南省昆明市西昌路295号, 昆明医学院第一附属医院感染病科. jingyoukm@126.com
电话: 0871-5324888
收稿日期: 2006-12-29 接受日期: 2007-01-20
Advances in the researches on hepatitis B virus genotyping and its clinical significance
Jing You, Lin Zhuang, Hong-Ying Chen, Hai-Qiu Yang, Bao-Zhang Tang, Meng-Ling Huang
Jing You, Hong-Ying Chen, Hai-Qiu Yang, Bao-Zhang Tang, Meng-Ling Huang,Department of Infectious Diseases, the First Affiliated Hospital of Kunming Medical College, Kunming 650032, Yunnan Province, China
Lin Zhuang,Department of Hepatopathy, the Third People’s Hospital of Kunming Municipality, Kunming 650041, Yunnan Province, China
Correspondence to:Dr. Jing You, Department of Infectious Diseases, the First Affiliated Hospital of Kunming Medical College, Kunming 650032, Yunnan Province, China. jingyoukm@126.com
Received:2006-12-29 Accepted:2007-01-20
Abstract
The genotyping of hepatitis B virus (HBV) is a highlight of the studies associated with chronic hepatitis B inside and outside the country nowadays. HBV infection can lead to chronic carriage of the virus and progressive liver disease, including liver cirrhosis and hepatocellular carcinoma. The serological heterogeneity of HBsAg has been well established. HBV isolates have been classified into 10 different subtypes according to the antigenic determinants of their HBsAg. However, the classification of HBV by serologic subtyping is not rational because a single point mutation at the S gene may result in a change in subtype. Therefore, worldwide HBV isolates have been classified into eight genotypes: A, B, C, D, E, F, G and H, based on the comparison of complete HBV genomes, which is the gold standard for genotyping. The eight genotypes have a distinct characteristic geographical distribution and an HBV genotypic difference in HBV pathogenicity ......
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