利用组织芯片技术研究P73和mP53基因编码蛋白在胃癌中的表达及意义
胃癌;组织芯片;免疫组化;P73;突变型P53,林志,辛彦,吴东瑛,林志,通讯作者:,ClinicopathologicalsignificancesofP73andP53proteinexpressioningast
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林志, 辽宁省肿瘤医院内三科 辽宁省沈阳市 110014
辛彦, 吴东瑛, 中国医科大学附属第一医院肿瘤研究所第四研究室 辽宁省沈阳市 110001
林志, 2004-2006年中国医科大学肿瘤学硕士, 主治医师, 主要从事肿瘤临床与基础研究.
国家自然科学基金资助项目, No. 30371607
教育部博士点专项基金资助项目, No. 20040159021
通讯作者: 辛彦, 110001, 辽宁省沈阳市和平区南京北街155号, 中国医科大学附属第一医院肿瘤研究所第四研究室.
yxin@mail.cmu.edu.cn
收稿日期: 2006-10-18 接受日期: 2006-11-16
Clinicopathological significances of P73 and P53 protein expression in gastric carcinomas with tissue microarray technique
Zhi Lin, Yan Xin, Dong-Ying Wu
Zhi Lin,the Third Department of Internal Medicine, Cancer Hospital, Shenyang 110014, Liaoning Province, China
Yan Xin, Dong-Ying Wu,the Fourth Laboratory of Cancer Institute, the First Affiliated Hospital of China Medical University, Shenyang 110001, Liaoning Province, China
Supported byNational Natural Science Foundation of China, No. 30371607, and the Specialized Research Fund for the Doctoral Program of Higher Education, No. 20040159021
Correspondence to:Yan Xin, the Fourth Laboratory of Cancer Institute, the First Affiliated Hospital of China Medical University, Shenyang 110001, Liaoning Province, China. yxin@mail.cmu.edu.cn
Received:2006-10-18 Accepted:2006-11-16
Abstract
AIM: To investigate the expression of P73 and mutant P53 (mP53) gene coding proteins and their significances in gastric carcinoma.
METHODS: Two tissue microarray blocks containing 104 cases of gastric cancer and precancerous lesions (1.0 mm each in diameter) was constructed. SABC immunohistochemical stainning was used to detect the expression of P73 and mP53 proteins and the correlation between their roles and the pathological behavior of gastric carcinoma was investigated.
RESULTS: The positive rate of P73 protein was significantly higher in gastric cancer, intestinal metaplasia and atypical hyperplasia than that in the normal tissues (90.1%, 44.0%, 80 ......
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