酒精性肝炎的治疗进展
酒精性肝炎;细胞凋亡;治疗,陈晓超,刘树滔,陈躬瑞,饶平凡,通讯作者:,Advancesintreatmentofalcoholichepatitis,Xiao-ChaoChen,Shu-TaoLiu,Gong-RuiChen,Ping-FanRao,Corresp
 |
| 第7页 |
 |
| 第1页 |
参见附件(863KB，7页)。
陈晓超, 刘树滔, 陈躬瑞, 饶平凡, 福州大学生物工程研究所 福建省福州市 350002
通讯作者: 饶平凡, 350002, 福建省福州市, 福州大学生物工程研究所. pfrao@fzu.edu.cn
电话: 0591-87893047 传真: 0591-83732462
收稿日期: 2007-02-06 接受日期: 2007-03-07
Advances in treatment of alcoholic hepatitis
Xiao-Chao Chen, Shu-Tao Liu, Gong-Rui Chen, Ping-Fan Rao
Xiao-Chao Chen, Shu-Tao Liu, Gong-Rui Chen, Ping-Fan Rao,Institute of Biotechnology, Fuzhou University, Fuzhou 350002, Fujian Province, China
Correspondence to: Ping-Fan Rao, Institute of Biotechnology, Fuzhou University, 523 Gongye Road, Fuzhou 350002, Fujian Province, China. pfrao@fzu.edu.cn
Received:2007-02-06 Accepted:2007-03-07
Abstract
Alcoholic hepatitis is a serious liver disease that may lead to cirrhosis and carcinoma, and the short-term mortality rate is fairly high in severe patients. Various strategies have been tested over the decades and none has shown any consistent benefit but the corticosteroids. Until now hepatic transplantation is the best solution to the patients with severe alcoholic hepatitis, but the timing and indications for transplantation are still problematic. Recent advances in the understanding of alcoholic hepatitis, including the roles of hepatocyte apoptosis, oxidative stress and cytokines, have provided a new opportunity to discover specific therapies for alcoholic hepatitis.
Key Words: Alcoholic hepatitis; Cell apoptosis; Therapeutics
Chen XC, Liu ST, Chen GR, Rao PF. Advances in treatment of alcoholic hepatitis. Shijie Huaren Xiaohua Zazhi 2007;15(10):1130-1136
摘要
酒精性肝炎往往导致肝硬化及肝癌, 其重症患者短期死亡率相当高. 迄今为止, 尚无任何药物可以根治这一顽疾, 现有临床治疗仅停留于对病情的缓解和营养补充层次. 肝脏移植是酒精性肝炎重症患者最佳的、也是最无奈的选择, 但他仍然面临移植手术时机和患者适应症的选择问题. 近年随着酒精性肝炎发病机制的逐渐阐明, 揭示了肝细胞凋亡以及各种细胞因子在其病程发展中所扮演的重要角色, 由此引发了新一轮寻找酒精性肝炎特效疗法的热潮.
关键词: 酒精性肝炎; 细胞凋亡; 治疗
陈晓超, 刘树滔, 陈躬瑞, 饶平凡. 酒精性肝炎的治疗进展. 世界华人消化杂志 2007;15(10):1130-1136
0 引言
近年随着全球酒精消费量的猛增, 酒精性肝炎的发病率也不断攀升 ......
您现在查看是摘要介绍页，详见PDF附件(863KB，7页)。