复合乳酸菌对不同营养治疗途径的重症急性胰腺炎大鼠肠屏障功能的影响
重症急性胰腺炎;肠屏障功能;乳酸菌;肠内营养;肠外营养,陈凌云,蔡东联,钟燕,耿珊珊,韩婷,林健,陈凌云,通讯作者:,Influenceofdifferentnutritionalsupportwithcompoundla
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陈凌云, 蔡东联, 钟燕, 耿珊珊, 韩婷, 中国人民解放军第二军医大学附属长海医院临床营养科 上海市 200433
林健, 江苏泰州美通药业有限公司 江苏省泰州市 225300
陈凌云, 2006年第二军医大学临床营养学博士, 主要从事临床疾病的营养治疗研究.
长海医院联合攻关基金资助项目, No. 20031119
通讯作者: 蔡东联, 200433, 上海市长海路174号, 中国人民解放军第二军医大学附属长海医院临床营养科.
nutrition1226@sohu.com
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收稿日期: 2007-01-08 接受日期: 2007-01-31
Influence of different nutritional support with compound lactobacilli on intestinal barrier function of rats with severe acute pancreatitis
Ling-Yun Chen, Dong-Lian Cai, Jian Lin, Yan Zhong, Shan-Shan Geng, Ting Han
Ling-Yun Chen, Dong-Lian Cai, Yan Zhong, Shan-Shan Geng, Ting Han,Department of Clinical Nutrition, Changhai Hospital Affiliated to the Second Millitary Medical University of Chinese PLA, Shanghai 200433, China
Jian Lin,Taizhou General Pharmaceutical Company Limited, Taizhou 225300, Jiangsu Province, China
Supported by the United Key Project of Changhai Hospital, No. 20031119
Correspondence to:Dong-Lian Cai, Department of Clinical Nutrition, Changhai Hospital Affiliated to the Second Military Medical University, Shanghai 200433, China. nutrition1226@sohu.com
Received:2007-01-08 Accepted:2007-01-31
Abstract
AIM: To investigate the influence of different nutritional support with compound lactobacilli on the intestinal barrier function in rats with severe acute pancreatitis (SAP) and its mechanism.
METHODS: SAP model was established in male Sprague Dawley rats via injection of l mL of 38 g/L sodium taurocholate beneath the pancreatic capsule. A total of 96 rats were randomly divided into 6 groups (n = 16): sham-operation with early enteral nutrition support (Sham-EEN), ENN group, EEN with compound lactobacilli (EEN + Lac) group, sham-operation with parenteral nutrition support (Sham-PN), PN group and PN with compound lactobacilli (PN + Lac) group. Half of rats in each group were killed on the 4th and 7th day respectively to determine the bacterial translocation (BT) in live and mesenteric lymph node (MLN), endotoxin (ET) in plasma, intestinal transit index, epithelial cell apoptosis in intestinal barrier (by TUNEL), protein content in small intestinal mucosa (by bicinchoninic acid), and SIgA content in small intestinal mucus (by enzyme-linked immunosorbent assay) ......
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