热休克蛋白70系列与应激性溃疡之间的相互关系
热休克蛋白;应激性溃疡;胃黏膜保护,王鹤,曲彦,通讯作者:,Relationshipbetweenheatshockprotein70andstressulcer,HeWang,YanQu,Correspondenceto:,Rec
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王鹤, 青岛大学医学院护理学院 山东省青岛市 266023
曲彦, 青岛大学医学院附属市立医院ICU 山东省青岛市 266011
通讯作者: 曲彦, 266011, 山东省青岛市, 青岛大学医学院附属市立医院ICU. qdquyan@yahoo.com.cn
电话: 0532-86969701
收稿日期: 2007-01-02 接受日期: 2007-01-20
Relationship between heat shock protein 70 and stress ulcer
He Wang, Yan Qu
He Wang,Nursing School of Qingdao University Medical College, Qingdao 2660023, Shandong Province, China
Yan Qu,Intensive Care Unit, Qingdao Municipal Hospital Affiliated to Qingdao University Medical College, Qingdao 266011, Shandong Province, China
Correspondence to:Yan Qu, 266011, Intensive Care Unit, Qingdao Municipal Hospital Affiliated to Qingdao University Medical College, Qingdao 266023, Shandong Province, China. qdquyan@yahoo.com.cn
Received:2007-01-02 Accepted:2007-01-20
Abstract
Biologic cells produce a series of stress reaction after being attacked by various kinds of physical and chemical factors, which induces the expression of heat shock proteins (HSPs). As the most conservative protein of HSPs, HSP70 family was studied most. Stress can induce gastric mucosal damage and reduce the protective function of mucosal barrier, resulting in the formation of stress ulcer. At the same, stress can accelerate the synthesis of HSP70, but in turn, HSP70 can prevent the occurrence of stress ulcer, inhibit the apoptosis of gastric mucosal cells and promote the healing of gastric ulcer. In this article, we reviewed the regulation and main classification of HSPs, the expression of HSPs and its role in stress ulcer, and several drugs (targeting on the induction of HSP expression) for the protection of gastric mucosa.
Key Words: Heat shock protein; Stress ulcer; Gastric mucosal protection
Wang H, Qu Y. Relationship between heat shock protein 70 and stress ulcer. Shijie Huaren Xiaohua Zazhi 2007;15(10):1121-1125
摘要
生物细胞在受到各种理化因素刺激后, 可以产生一系列的应激反应, 诱导热休克蛋白(heat shock protein, HSP)表达 ......
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