TβRⅡ, MMP-7, TIMP-2表达及在HNPCC侵袭转移中的作用
遗传性非息肉病性大肠癌;转化生长因子β;转化生长因子βⅡ型受体;基质金属蛋白酶-7;金属蛋白酶组织抑制因子-2;病理;免疫组化,TβRⅡ,MMP-7,TIMP-2表达及在HNPCC侵袭转移中的作用,顾国利,魏学明,王石林,任力,胡益云,李德昌,顾国利,通讯作者:,Expressionof
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顾国利, 魏学明, 王石林, 空军总医院普通外科 北京市 100036
任力, 胡益云, 李德昌, 空军总医院病理科 北京市 100036
顾国利, 2004年中国医科大学外科学普通外科专业硕士生, 主要从事结直肠癌临床肿瘤学的研究.
通讯作者: 王石林, 100036, 北京市, 空军总医院普通外科. wangshilin@medmail.com.cn
电话: 010-68410099-6302
收稿日期: 2007-01-16 接受日期: 2007-02-16
Expression of transforming growth factor β receptor Type Ⅱ, matrix metalloproteinase-7 and tissue inhibitor of metalloproteinase-2 and their roles in the invasion and metastasis of hereditary nonpolyposis colorectal cancer
Guo-Li Gu, Xue-Ming Wei, Li Ren, Shi-Lin Wang, Yi-Yun Hu, De-Chang Li
Guo-Li Gu, Xue-Ming Wei, Shi-Lin Wang,Department of General Surgery, General Hospital of Chinese PLA Air force, Beijing 100036, China
Li Ren, Yi-Yun Hu, De-Chang Li,Department of Pathology, General Hospital of Chinese PLA Air force, Beijing 100036, China
Correspondence to:Shi-Lin Wang, Department of General Surgery, General Hospital of Chinese PLA Air force, Beijing 100036, China. wangshilin@medmail.com.cn
Received:2007-01-16 Accepted:2007-02-16
Abstract
AIM: To investigate the roles of transforming growth factor β receptor Type Ⅱ (TβRⅡ), matrix metalloproteinase-7 (MMP-7) and tissue inhibitor of metalloproteinase-2 (TIMP-2) expression in the invasion and metastasis of human hereditary nonpolyposis colorectal cancer (HNPCC).
METHODS: Immunohistochemical staining was used to detect the expressions of TβRⅡ, MMP-7 and TIMP-2 protein in 30 cases of sporadic colorectal cancer (sporadic CRC) and 30 cases of HNPCC, and their corresponding clinical data were analyzed retrospectively.
RESULTS: The positive rates of TβRⅡ, MMP-7 and TIMP-2 expression in HNPCC were 40.0%, 46.7% and 63.3% respectively, while in sporadic CRC, the rates were 73.3%, 86.7% and 20.0% respectively. The ratio of MMP-7(+~++) to TIMP-2(-) in sporadic CRC was higher while that of MMP-7(-) to TIMP-2(+~++) was lower significantly than that in HNPCC ......
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