microRNA表达谱与消化器官肿瘤的发生、诊断及治疗
microRNA;表达谱;肿瘤;消化器官,李欣,李小青,黄士昂,通讯作者:,MicroRNAprofilesandinitiation,diagnosisandtreatmentofcancersindigestiveorgans,X
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李欣, 李小青, 黄士昂, 华中科技大学同济医学院附属协和医院干细胞中心/湖北省生物靶向治疗重点实验室 湖北省武汉市 430022
国家杰出青年基金资助项目, No. 30225038
通讯作者: 黄士昂, 430022, 湖北省武汉市, 华中科技大学同济医学院附属协和医院干细胞中心/湖北省生物靶向治疗重点实验室. sa2huang@hotmail.com电话: 027-85726015
收稿日期: 2007-02-08 接受日期: 2007-02-21
MicroRNA profiles and initiation, diagnosis and treatment of cancers in digestive organs
Xin Li, Xiao-Qing Li, Shi-Ang Huang
Xin Li, Xiao-Qing Li, Shi-Ang Huang,Stem Cell Center, Union Hospital of Tongji Medical College, Huazhong University of Science and Technology; Key Laboratory for Bio-targeted Therapy of Hubei Province, Wuhan 430022, Hubei Province, China
Supported bythe National Science Foundation for Distinguished Young Scholars, No. 30225038
Correspondence to:Shi-Ang Huang, Stem Cell Center, Union Hospital of Tongji Medical College, Huazhong University of Science and Technology; Key Lab for Bio-targeted Therapy of Hubei Province, Wuhan 430022, Hubei Province, China. sa2huang@hotmail.com
Received: 2007-02-08 Accepted:2007-02-21
Abstract
MicroRNA (miRNA) is a kind of small non-coding RNA containin 21 to 23 nucleotides in length that down-regulates gene expression during various crucial cell processes such as development, proliferation, differentiation and apoptosis. Recent studies supported an important role of miRNA in the initiation and progression of human malignancies. Some miRNAs may function as oncogenes or tumor suppressors. It is found that several miRNAs are directly involved in human cancers of digestive organs, including liver, colon, stomach, pancreas and bile duct. In addition, miRNA expression profiling of tumors in digestive organs has identified signatures associated with diagnosis, staging, progression, prognosis and response to treatment. Profiling has also been exploited to identify miRNA genes that might represent downstream targets of activated oncogenic pathways, or target protein coding genes involved in cancer ......
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