软脉灵对大鼠非酒精性脂肪肝的预防作用
软脉灵;非酒精性脂肪性肝病;肝脏指数;病理学检查;血液生化;抗氧化剂,卢明芳,王雯,卢明芳,通讯作者:,PreventiveeffectofRuanmailingonnon-alcoholicfattyliverdiseaseinrats,Min
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卢明芳, 第一军医大学福州临床医学院, 中国人民解放军南京军区福州总医院消化科 福建省福州市 350025
王雯, 中国人民解放军南京军区福州总医院消化科 福建省福州市 350025
卢明芳, 第一军医大学2007届硕士研究生, 主要从事脂肪肝的基础与临床研究.
通讯作者: 卢明芳, 350025, 福建省福州市西环北路156号, 南京军区福州总医院消化科. lumingfangdoc@163.com
电话: 0591-24937074
收稿日期: 2007-03-04 接受日期: 2007-04-12
Preventive effect of Ruanmailing on non-alcoholic fatty liver disease in rats
Ming-Fang Lu, Wen Wang
Ming-Fang Lu,Fuzhou Clinical Medical College of the First Military Medical University; Department of Gastroenterology, Fuzhou General Hospital of Nanjing Military Command, Fuzhou 350025, Fujian Province, China
Wen Wang,Department of Gastroenterology, Fuzhou General Hospital of Nanjing Military Command, Fuzhou 350025, Fujian Province, China
Correspondence to:Ming-Fang Lu, Fuzhou Clinical Medical College of the First Military Medical University; Department of Gastroenterology, Fuzhou General Hospital of Nanjing Military Command, Fuzhou 350025, Fujian Province, China. lumingfangdoc@163.com
Received:2007-03-04 Accepted:2007-04-12
Abstract
AIM: To investigate the effect of Ruanmailing in preventing nonalcoholic fatty liver disease (NAFLD) in rats.
METHODS: Rat models of NAFLD were established by high-fat diet. A total of 90 male Sprague Dawley rats were randomly divided into group A, B and C, fed with high-fat diet, high-fat diet plus Ruanmailing (ig), and normal basic food. Ten rats of each group were sacrificed at the 8th, 12th and 16th week, and meanwhile, the liver index, biochemical indicators in serum and liver tissues and the hepatic pathological changes were observed.
RESULTS: At the 16th week in group B, the liver index was decreased significantly in comparison with that in group A (F = 51.626, P = 0.000); the serum levels of cholesterol (CHOL), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were reduced markedly (2 ......
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