RNA干扰在胃癌治疗中的研究进展
RNA干扰;胃癌;基因治疗,章琎,方国恩,王嘉锋,通讯作者:,ProgressofRNAinterferenceinthetherapyofgastriccancer,JinZhang,Guo-EnFang,Jia-FengWang,Correspon
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章琎, 方国恩, 王嘉锋, 中国人民解放军第二军医大学长海医院普外科 上海市 200433
通讯作者: 章琎, 200433, 上海市, 中国人民解放军第二军医大学长海医院普外科. zhangjin_sh@126.com
电话: 021-65504407
收稿日期: 2006-12-04 接受日期: 2007-02-12
Progress of RNA interference in the therapy of gastric cancer
Jin Zhang, Guo-En Fang, Jia-Feng Wang
Jin Zhang, Guo-En Fang, Jia-Feng Wang,Department of General Surgery, Changhai Hospital of the Second Military Medical University, Shanghai 200433, China
Correspondence to: Jin Zhang, Department of General Surgery, Changhai Hospital of the Second Military Medical University, Shanghai 200433, China. zhangjin_sh@126.com
Received:2006-12-04 Accepted:2007-02-12
Abstract
RNA interference (RNAi) is a new gene-silencing technique, which is a post-transcriptional gene silencing mediated by double-stranded RNA, resulting in the sequence-specific silence of target gene. RNAi technique has been applied widely in the research of various tumors, and most of the results have shown that it could specifically inhibited the expression of oncogenes, cancer-related genes and mutant genes, so as to suppress the occurrence and development of tumors. Meanwhile, explorations have also been performed on the therapy of gastric cancer, and some significant advances have been obtained. RNAi technique can not only act on the target genes directly, but also treat gastric cancer indirectly by restraining the angiogenesis. Furthermore, RNAi technique can be used to resist the multi-drug resistance during chemotherapy.
Key Words: RNA interference; Gastric cancer; Gene therapy
Zhang J, Fang GE, Wang JF. Progress of RNA interference in the therapy of gastric cancer. Shijie Huaren Xiaohua Zazhi 2007;15(11):1252-1256
摘要
RNA干扰(RNAi)是近几年发展起来的一种新兴的基因沉默技术, 他是由双链RNA介导的靶向基因序列特异性转录后沉默机制. 目前, RNAi技术已被广泛应用于各种肿瘤研究, 结果发现其可特异地抑制癌基因、癌相关基因或突变基因的过度表达, 从而抑制肿瘤的发生、发展. 同时RNAi技术在胃癌治疗方面也进行了许多积极的探索, 取得了一些突破性进展 ......
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