β-榄香烯对实验性肝纤维化大鼠TGF-β1、a-SMA、Col-Ⅰ表达的影响
肝纤维化;β-榄香烯;转化生长因子β1;a平滑肌肌动蛋白;Ⅰ型胶原;免疫组化,β-榄香烯对实验性肝纤维化大鼠TGF-β1、a-SMA、Col-Ⅰ表达的影响,胡胜军,杨玲,彭汉光,朱清静,胡胜军,通讯作者:,Effectofβ-elemeneontheexpressionoftransfo
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胡胜军, 杨玲, 彭汉光, 华中科技大学同济医学院附属协和医院 湖北省武汉市 430022
朱清静, 武汉市传染病医院 湖北省武汉市 430022
胡胜军, 华中科技大学同济医学院04级硕士研究生, 主要从事中西医结合肝脏疾病的研究.
国家自然科学基金资助项目, No. 30500658
通讯作者: 杨玲, 430022, 湖北省武汉市解放大道1277号, 华中科技大学同济医学院附属协和医院消化内科.
yang_lng@yahoo.com.cn
电话: 027-85726381
收稿日期: 2006-11-30 接受日期: 2007-01-20
Effect of β-elemene on the expression of transforming growth factor-β1, a-smooth muscle actin and collagen-Ⅰ in rats with hepatic fibrosis
Sheng-Jun Hu, Ling Yang, Qing-Jing Zhu, Han-Guang Peng
Sheng-Jun Hu, Ling Yang, Han-Guang Peng,Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, Hubei Province, China
Qing-Jing Zhu,Wuhan Hospital of Infectious Diseases, Wuhan 430022, Hubei Province, China
Supported byNational Natural Science Foundation of China, No. 30500658
Correspondence to:Ling Yang, Department of Gastroenterology, Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan 430022, Hubei Province, China. yang_lng@yahoo.com.cn
Received:2006-11-30 Accepted:2007-01-20
Abstract
AIM: To study the effect of zedoary rhizome extract (β-elemene) on the expression of transforming growth factor-β1 (TGF-β1), α-smooth muscle actin (α-SMA) and type Ⅰ collagen-Ⅰ (Col-Ⅰ) in rats with hepatic fibrosis.
METHODS: The experimental model of hepatic fibrosis was induced by hypodermical injection of carbon tetrachloride (CCl4) in Wistar male rats. β-elemene was intraperitonealy administered into the rats for 8 weeks (0.1 mL/100 g body weight per day). The samples were stained with hematoxylin and eosin for histopathological examination. Masson staining was used to observe the liver fibrosis of rats. Liver functions were measured by enzymatic kinetic analysis. The levels of a-SMA, TGF-β1 and Col-Ⅰ expression in liver tissues were measured by SP immunohistochemistry method ......
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