CHFR和mp53基因编码蛋白在胃癌组织中的表达及临床病理学意义
CHFR基因;突变型p53;胃癌;免疫组化,高余佳,辛彦,张赛楠,张家华,吴东瑛,通讯作者:,Proteinexpressionofcheckpointwithforkheadassociatedandringfingerandm
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高余佳, 辽宁省肿瘤医院内六科 辽宁省沈阳市 110042
辛彦, 张赛楠, 张家华, 吴东瑛, 中国医科大学附属一院肿瘤研究所第四研究室 辽宁省沈阳市 110001
高余佳, 2005-2008年中国医科大学肿瘤学博士, 副主任医师, 主要从事肿瘤临床及基础研究, 现任职于辽宁省肿瘤医院.
国家自然科学基金资助项目, No. 30371607
教育部博士点专项基金资助项目, No. 20040159021
通讯作者: 辛彦, 110001, 辽宁省沈阳市和平区南京北街155号, 中国医科大学附属一院肿瘤研究所第四研究室.
yxin@mail.cum.edu.cn
电话: 024-24116843
收稿日期: 2007-04-09 接受日期: 2007-04-22
Protein expression of checkpoint with fork head associated and ring finger and mutant p53 and their clinicopathological significances in gastric cancer
Yu-Jia Gao, Yan Xin, Sai-Nan Zhang, Jia-Hua Zhang, Dong-Ying Wu
Yu-Jia Gao, the Sixth Department of Internal Medicine, Cancer Hospital of Liaoning Province, Shenyang 110042, Liaoning Province, China
Yan Xin, Sai-Nan Zhang, Jia-Hua Zhang, Dong-Ying Wu, the Fourth Laboratory of Cancer Institute, the First Affiliated Hospital of China Medical University, Shengyang 110001, Liaoning Province, China
Supported by National Natural Science Foundation of China, No. 30371607, and the Specialized Research Fund for the Doctoral Program of Education Ministry, No. 20040159021
Correspondence to: Professor Yan Xin, the Fourth Laboratory of Cancer Institute, the First Affiliated Hospital, China Medical University, Shengyang 110001, Liaoning Province, China. yxin@mail.cum.edu.cn
Received: 2007-04-09 Accepted: 2007-04-22
Abstract
AIM: To investigate the relationship between the expression of checkpoint with fork head associated and ring finger (CHFR) and P53 protein in gastric cancer (GC) and the clinicopathologic characteristics, and to explore the correlated molecular mechanism of CHFR and p53 genes in gastric carcinogenesis.
METHODS: Five paraffin blocks of tissue microarray were constructed using a Tissue Array Machine (Steve Leighton Beecher Instruments, USA), including 151 cases of primary GC (101 cases with matched normal mucosa, intestinal metaplasia or dysplasia) ......
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