隐匿性慢性乙型肝炎肝内CD4+和CD8+的表达与相关分析
隐匿性乙型肝炎;肝组织病理;免疫组化;原位杂交;CD4+;CD8+,肖影群,章萍,通讯作者:,ExpressionofCD4+andCD8+inliverofpatientswithocculthepatitisBvirusinfect
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肖影群, 章萍, 江西省南昌市第九医院(南昌大学医学院附属感染医院)病理科 江西省南昌市 330002
通讯作者: 肖影群, 330002, 江西省南昌市洪都中大道167号, 江西省南昌市第九医院(南昌大学医学院附属感染医院)病理科. xiaoyq2008@126.com
电话: 0791-7069554 传真: 0791-7069636
收稿日期: 2007-03-07 接受日期: 2007-04-02
Expression of CD4+ and CD8+ in liver of patients with occult hepatitis B virus infection
Ying-Qun Xiao, Ping Zhang
Ying-Qun Xiao, Ping Zhang,Department of Pathobiology, Ninth Hospital of Nanchang (Affiliated Infectious Disease Hospital of Nanchang University), Nanchang 330002, Jiangxi Province, China
Correspondence to:Ying-Qun Xiao, Department of Pathobiology, Ninth Hospital of Nanchang, 167 Hongdu Central Road, Nanchang 330002, Jiangxi Province, China. xiaoyq2008@126.com
Received:2007-03-07 Accepted:2007-04-02
Abstract
AIM: To study the relationship between the expression and distribution of CD4+ and CD8+ T lymphocytes and disease severity in liver with occult HBV infection.
METHODS: Sixty-three in-patient cases without clinical syndromes or signs but shown to be HBV infected by pathological diagnosis of liver tissue obtained by needle aspiration biopsy were studied. CD4+ and CD8+ were detected by immunohistochemical staining, and HBV DNA was detected by in situ hybridization in formalin-fixed and paraffin-embedded sections.
RESULTS: CD4 positive cells showed increased expression in liver of patients with occult HBV infection in the areas having mononuclear macrophages. CD4 and CD8 positive cells were significant among pathological types (χ2 = 12.709, P < 0.05). There was no obvious difference of CD4+ between chronic hepatitis and occult hepatitis B virus infection.
CONCLUSION: Mononuclear macrophages were seen in areas of piecemeal and bridging necrosis in portal areas and their circumference. As liver damage developed, more CD4+ and CD8+ cells were expressed.
Key Words: Occult Hepatitis B; Pathobiology in live tissue; Immunohistochemical staining; In situ hybridization; CD4+; CD8+ ......
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