老年人急性药物性肝病临床分析30例
老年;急性药物性肝病;不良反应,林静,王亚丽,王海燕,通讯作者:,Reviewof30casesofacutedruginducedliverdiseaseintheelderly,JingLin,Ya-LiWang,Hai-YanWang,Corr
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林静, 王亚丽, 王海燕, 清华大学第一附属医院消化内科 北京市 100016
通讯作者: 林静, 100016, 北京市, 清华大学第一附属医院消化内科. wanghaiy@sohu.com
电话: 010-64312901
收稿日期: 2006-12-30 接受日期: 2007-01-10
Review of 30 cases of acute drug induced liver disease in the elderly
Jing Lin, Ya-Li Wang, Hai-Yan Wang
Jing Lin, Ya-Li Wang, Hai-Yan Wang,Department of Gastroenterology, First Affiliated Hospital of Tsing Hua University, Beijing 100016, China
Correspondence to: Jing Lin,Department of Gastroenterology, First Affiliated Hospital of Tsing Hua University, Beijing 100016, China. wanghaiy@sohu.com
Received:2006-12-30 Accepted:2007-01-10
Abstract
AIM: To review common inducing drugs and their clinical manifestations, to discuss the grouping and prognosis of acute drug induced liver disease (ADLD) in the elderly, and to enhance the diagnosis capabilities and management of ADLD.
METHODS: A retrospective-study to 30 cases of ADLD, chosen according to diagnosis standards.
RESULTS: The types of drugs inducing ADLD were as follows: 9 cases of traditional and herbal drugs (30.3%); 5 of antibiotics (16.7%); 3 each of nonsteroidal anti-inflammatory, iodized oil roentgenograph, and anti-hyperthyroidism drugs (30.0%); and 7 others (23.3%). Manifestations were: acute hepatocellular lesions, 20 cases (66.7%); acute cholestasis, 3 cases (10.0%); mixed type, 7 cases (23.3%). Curative effects were: 18 cases of a cure (60.0%), 8 improvements (26.7%), 2 deteriorations (6.7%), and 2 deaths (6.7%).
CONCLUSION: The elderly are more sensitive and have less reserved organ functions than younger age groups. Thus it is easier for acute drug induced liver disease to occur in the elderly, especially in patients with other chronic diseases ......
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