三叶因子1的研究与进展
三叶因子1;功能;肿瘤,蔡稼燕,任建林,张靖,任建林,通讯作者:,Reviewofresearchandprogressrelatedtotrefoilfactor1,Jia-YanCai,ian-LinRen,JingZhang,Correspondencet
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蔡稼燕, 福建医科大学2006级硕士研究生 福建省福州市 350000
任建林, 张靖, 厦门大学附属中山医院消化内科 厦门大学消化疾病研究所 厦门市消化病诊治中心 厦门大学附属中山医院博士后工作站 福建省厦门市 361004
任建林, 医学博士, 教授, 主任医师, 博士生导师, 厦门大学附属中山医院消化内科主任, 厦门大学消化疾病研究所常务副所长, 厦门市消化疾病诊治中心常务副主任, 主要从事胃肠黏膜病变与胃肠道肿瘤的相关研究.
通讯作者: 任建林, 361004, 福建省厦门市湖滨南路201号, 厦门大学附属中山医院消化内科, 厦门大学消化疾病研究所, 厦门市消化疾病诊治中心. jianlinr@msn.com
电话: 0592-2292017 传真: 0592-2292017
收稿日期: 2007-06-05 修回日期: 2007-07-26
Review of research and progress related to trefoil factor 1
Jia-Yan Cai, Jian-Lin Ren, Jing Zhang
Jia-Yan Cai, Fujian Medical University, Fuzhou 350000, Fujian Province, China
Jian-Lin Ren, Jing Zhang, Department of Gastroenterology, Zhongshan Hospital Affiliated to Medical College of Xiamen University; Gastroenterology Institute of Xiamen University; Gastroenterology Diagnosis Center of Xiamen City; Postdoctoral Workstation, Zhongshan Hospital Affiliated to Medical College of Xiamen University, Xiamen 361004, Fujian Province, China
Correspondence to: Jian-Lin Ren, Department of Gastroenterology, Zhongshan Hospital Affiliated to Medical College of Xiamen University, 201 Hubin South Road, Xiamen 361004, Fujian Province, China. jianlinr@msn.com
Received: 2007-06-05 Revised: 2007-07-26
Abstract
There is convincing evidence that trefoil factor 1 (TFF1), the first member of the trefoil factor family, plays an important role in the gastrointestinal barrier function and epithelial restitution. TFF1 is involved in gastrointestinal protection, in combination with mucin. TFF1 contributes to the different steps of mucosal restitution, especially the regulation of cell–cell contact and cell migration. Recently, TFF1 has been shown to interfere with crucial biological processes such as cell migration, proliferation, differentiation and apoptosis, and angiogenesis. TFF1 delays the G1-S phase transition of the cell cycle, and reduces gastrointestinal-cell-induced apoptosis ......
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