汉防己甲素对肝硬化大鼠胃黏膜微循环及超微结构的影响
门脉高压;门脉高压性胃病;汉防己甲素;超微结构;胃黏膜,黄会芳,霍丽娟,吴晓宁,通讯作者:,Effectoftetrandrineonmicrocirculationandultramicrostructureofgastricmucosain
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黄会芳, 霍丽娟, 山西医科大学第一医院消化科 山西省太原市 030001
吴晓宁, 首都医科大学附属北京友谊医院肝病中心 北京市 100050
通讯作者: 黄会芳, 030001, 山西省太原市, 山西医科大学第一医院消化科. shxhhf@126.com
电话: 0351-4639511
收稿日期: 2007-03-07 修回日期: 2007-07-14
Effect of tetrandrine on microcirculation and ultramicrostructure of gastric mucosa in rats with portal hypertension
Hui-Fang Huang, Li-Juan Huo, Xiao-Ning Wu
Hui-Fang Huang, Li-Juan Huo, Department of Gastroenterology, the First Affiliated Hospital of Shanxi Medical University, Taiyuan 030001, Shanxi Province, China
Xiao-Ning Wu, Hepatology Center, Beijing Friendship Hospital, Capital University of Medical Sciences, Beijing 100050, China
Correspondence to: Hui-Fang Huang, Department of Gastroenterology, the First Affiliated Hospital of Shanxi Medical University, Taiyuan 030001, Shanxi Province, China. shxhhf@126.com
Received: 2007-03-07 Revised: 2007-07-14
Abstract
AIM: To evaluate the effects of tetrandrine on lowering portal vein pressure (PVP) and improving the microcirculation and ultramicrostructure of gastric mucosa in rats with portal hypertension.
METHODS: Except for normal rats in the control group, all rats were established as portal hypertension (PHT) models, and then randomly divided into model (M), tetrandrine (T) and propranolol (P) groups. All rats were sacrificed after 15 d therapy.
RESULTS: Levels of PVP, alanine aminotransferase (ALT), hyaluronic acid (HA), and procollagen type Ⅲ (PCⅢ) were significantly decreased in the T group compared with those in the M group (P < 0.01, P < 0.05), whereas heart rate (HR) and mean arterial pressure (MAP) were not. In the P group the levels of PVP and HR were significantly decreased (P < 0.01, P < 0.05). Levels of MAP, ALT, HA and PCIII were not decreased. The area and diameter of gastric mucosal capillaries were significantly decreased (P < 0.01), and the ultramicrostructure of gastric mucosa was significantly improved in the T and P groups ......
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