四氯化碳诱发大鼠肝纤维化自发逆转中库普弗细胞与星状细胞的分布
四氯化碳;库普弗细胞;肝纤维化;可逆性,金英姬,金仁顺,朴东明,通讯作者:,Distributionofkupfferandhepaticstellatecellsduringspontaneousreversiblecarbon-te
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金英姬, 金仁顺, 朴东明, 延边大学附属医院病理科 吉林省延吉市 133000
通讯作者: 朴东明, 133000, 吉林省延吉市局子街1327号, 延边大学附属医院病理科. pdm1117@hotmail.com
电话: 0433-2660121 传真: 0433-2513610
收稿日期: 2007-02-02 修回日期: 2007-07-02
Distribution of kupffer and hepatic stellate cells during spontaneous reversible carbon-tetrachloride-induced liver fibrosis in rats
Ying-Ji Jin, Ren-Shun Jin, Dong-Ming Piao
Ying-Ji Jin, Ren-Shun Jin, Dong-Ming Piao, Department of Pathology, the Affiliated Hospital of Yanbian University, Yanji 133000, Jilin Province, China
Correspondence to: Dong-Ming Piao, Department of Pathology, the Affiliated Hospital of Yanbian University, 1327 Juzi Street, Yanji 133000, Jilin Province, China. pdm1117@hotmail.com
Received: 2007-02-02 Revised: 2007-07-02
Abstract
AIM: To investigate the distribution and significance of kupffer cells (KCs) and hepatic stellate cells (HSCs) during spontaneous reversible carbon tetrachloride (CCl4)-induced liver fibrosis in rats.
METHODS: Rat liver fibrosis was induced by peritoneal injection of CCl4 (500 mL/L) for 8 weeks. Serum activity of alanine transaminase (ALT) and aspartate transaminase (AST), total protein (TP) content, ratio of liver/body weight, and area density of collagenous fiber were examined 8 and 12 weeks after injection. Meanwhile, the pathological changes in the liver were observed by light microscopy after Hematoxylin and eosin (HE) staining. The expression of ED1 and α-smooth muscle actin (α-SMA) was detected by immunohistochemical streptavdin-peroxidase-biotin (SP) method.
RESULTS: Compared with the control group, the levels of ALT (2568.18 ± 630.46 nkat/L vs 472.26 ± 167.37 nkat/L, P < 0.05) and AST (5845.84 ± 1353.27 nkat/L vs 1698.51 ± 663.30 nkat/L,P < 0.01), ratio of liver/body weight (3.900 ± 0.850 vs 2.560 ± 0.240, P < 0.001), and area of collagenous fiber (5.867 ± 1.127 vs 0.518 ± 0 ......
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