檞皮素对大鼠酒精性脂肪肝核转录因子表达的影响
酒精性脂肪肝;檞皮素;肿瘤坏死因子-α;核转录因子;大鼠,张禁,谭诗云,朱卫芳,蒋琳,程景辉,通讯作者:,EffectsofquercetinontheexpressionofnuclearfactorkappaBinalcoholicfattyl
 |
| 第1页 |
参见附件(556KB，4页)。
张禁, 谭诗云, 朱卫芳, 武汉大学人民医院消化内科 湖北省武汉市 430060
蒋琳, 武汉大学人民医院检验科 湖北省武汉市 430060
程景辉, 湖北省嘉鱼县人民医院内科 437200
张禁, 武汉大学人民医院硕士, 主要从事脂肪肝防治研究.
通讯作者: 谭诗云, 430060, 湖北省武汉市武昌区解放路238号, 武汉大学人民医院消化内科. tanshiyun@medmail.com.cn
电话: 027-88041919-2135
收稿日期: 2007-04-02 修回日期: 2007-07-21
Effects of quercetin on the expression of nuclear factor kappaB in alcoholic fatty liver of rats
Jin Zhang, Shi-Yun Tan, Lin Jiang, Wei-Fang Zhu, Jing-Hui Cheng
Jin Zhang, Shi-Yun Tan, Wei-Fang Zhu, Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei Province, China
Lin Jiang, Department of Laboratory, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei Province, China
Jing-Hui Cheng, Department of Medicine, Renmin Hospital of Jiayu Country, Jiayu 437200, Hubei Province, China
Correspondence to: Shi-Yun Tan, Department of Gastroenterology, Renmin Hospital of Wuhan University, 238 Jiefang Road, Wuchang District, Wuhan 430060, Hubei Province, China. tanshiyun@medmail.com.cn
Received: 2007-04-02 Revised: 2007-07-21
Abstract
AIM: To explore the effect and possible mechanism of quercetin on alcoholic fatty liver (AFL) in rats.
METHODS: Forty-eight male wistar rats were randomly divided into four groups: normal control, model, quercetin and naloxone groups. By the end of the fourth week, all rats were weighed, narcotized, sacrificed, and tested for expression levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT) and tumor necrosis factor-alpha (TNF-α) in plasma. Liver samples were analyzed for common histopathological changes and the expression of nuclear factor kappaB (NF-κB) was measured by immunohistochemical staining.
RESULTS: Levels of AST, ALT, and TNF-α in plasma were markedly lower in the quercetin and naloxone groups than the model group (quercetin, 150.7 ± 23 ......
您现在查看是摘要介绍页，详见PDF附件(556KB，4页)。