谷氨酰胺和地塞米松对脓毒症幼年大鼠肝脏肿瘤坏死因子-α与基质金属蛋白酶3的影响
谷氨酰胺;地塞米松;基质金属蛋白酶3;肝脏重塑,王虹,孙梅,周卓,通讯作者:,Effectsofglutamineanddexamethasoneontheexpressionoftumornecrosisfacto
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王虹, 孙梅, 中国医科大学附属第二医院(盛京医院)儿科 辽宁省沈阳市 110004
周卓, 中国医科大学附属第二医院(盛京医院)中心实验室 辽宁省沈阳市 110004
王虹, 2005年中国医科大学博士, 副教授, 主要从事小儿心肌损害研究.
辽宁省教育厅科研基金资助项目, No. 20122166
辽宁省科技厅科研基金资助项目, No. 20052091
通讯作者: 孙梅, 110004, 辽宁省沈阳市和平区三好街36号, 中国医科大学附属第二医院(盛京医院)儿科. sunm@cum2h.com
电话: 024-83955572
收稿日期: 2007-01-30 修回日期: 2007-07-20
Effects of glutamine and dexamethasone on the expression of tumor necrosis factor alpha and matrix metalloproteinase 3 in rat liver with sepsis
Hong Wang, Mei Sun, Zhuo Zhou
Hong Wang, Mei Sun, Department of Pediatrics, the Second Affiliated Hospital (Shengjing Hospital) of China Medical University, Shenyang 110004, Liaoning Province, China
Zhuo Zhou, Department of Center Laboratory, the Second Affiliated Hospital (Shengjing Hospital) of China Medical University, Shenyang 110004, Liaoning Province, China
Supported by: the Applied Basic Research Program of the Education Commission Foundation of Liaoning Province, No. 20122166 and the Applied Basic Research Program of the Science and Technology Commission Foundation of Liaoning Province, No. 20052091
Correspondence to: Mei Sun, Department of Pediatrics, the Second Affiliated Hospital (Shengjing Hospital) of China Medical University, 36 Sanhao Street, Heping District, Shenyang 110004, Liaoning Province, China. sunm@cum2h.com
Received: 2007-01-30 Revised: 2007-07-20
Abstract
AIM: To explore the effect of glutamine (Gln) and dexamethasone (Dex) on the production of tumor necrosis factor alpha (TNF-α) and matrix metalloproteinase 3 (MMP3) in the liver of young rats with endotoxemia.
METHODS: Endotoxemia models were established by intraperitoneal injection of lipopolysaccharide (LPS) in 88 18-day-old young wistar rats. The rats were then randomly divided into three groups: control group (C, normal saline 1 mL/kg ip, n = 8), LPS group (L, LPS 4 mg/kg ip, n = 40) and treatment group (T, LPS 4 mg/kg ip, followed 1 hour later by Dex 5 mg/kg plus 13 ......
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