小肠移植的研究进展
小肠移植;外科技术;免疫抑制;排斥;感染,朱亮,李幼生,黎介寿,通讯作者:,Advancesinsmallintestinaltransplantation,LiangZhu,You-ShengLi,Jie-ShouLi,Supportedby:,Correspond
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朱亮, 大连医科大学生理教研室 辽宁省大连市 116027
李幼生, 黎介寿, 南京军区南京总医院全军普外科研究所 江苏省南京市 210002
江苏省医学领军人才资助课题, No. 200710
辽宁省教育厅青年基金资助课题, No. 2004F088
国家973资助课题, No. 2003CB515502
通讯作者: 李幼生, 210002, 江苏省南京市, 南京军区南京总医院全军普外科研究所. zhuliang2001@nju.org.cn
电话: 025-86800137
收稿日期: 2007-08-11 修回日期: 2007-09-25
Advances in small intestinal transplantation
Liang Zhu, You-Sheng Li, Jie-Shou Li
Liang Zhu, Department of Physiology, Dalian Medical University, Dalian 116027, Liaoning Province, China
You-Sheng Li, Jie-Shou Li, Research Institute of General Surgery, Nanjing PLA General Hospital, Nanjing 210002, Jiangsu Province, China
Supported by: Outstanding Medical Academic leader program of Jiangsu Province, No. 200710; Science Fund for Young Scholars of the Education Department of Liaoning Province, No. 2004F088; Major State Basic Research Development Program of China (973 Program), No. 2003CB515502
Correspondence to: You-Sheng Li, Research Institute of General Surgery, Nanjing PLA General Hospital, Nanjing 210002, Jiangsu Province, China. zhuliang2001@nju.org.cn
Received: 2007-08-11 Revised: 2007-09-25
Abstract
Great progress has been achieved in of small bowel transplantation (SBT) over the past 20 years, SBT is now no longer considered an experimental procedure and has become a lifesaving therapy in patients with irreversible loss of intestinal function. The Transplant Registry has shown that 180 SBTs are performed each year. Current 1-yr patient and graft survival rates are 80%. Infection and acute rejection of the small bowel are still the most disturbing complications in patients undergoing SBT. This article summarizes recent advances its indications, evaluation of intestinal transplant candidates, surgical techniques, immunosuppressive therapy, rejection, and infection.
Key Words: Small bowel transplantation; Surgical techniques; Immunosuppressive therapy; Graft rejection; Infection ......
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