辣椒素对胃动力的影响及其机制
辣椒素;胃动力;机制,吴天军,彭燕,通讯作者:,Effectandmechanismofactionofcapsaicinongastricmotility,Tian-JunWu,YanPeng,Correspondenceto:,Received:,Revised
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吴天军, 彭燕, 泸州医学院附属医院消化内科 四川省泸州市 646000
通讯作者: 吴天军, 646000, 四川省泸州市, 泸州医学院附属医院消化内科. wutj21@163.com
电话: 0830-3165331
收稿日期: 2007-08-23 修回日期: 2007-10-24
Effect and mechanism of action of capsaicin on gastric motility
Tian-Jun Wu, Yan Peng
Tian-Jun Wu, Yan Peng, Department of Gastroenterology, Affiliated Hospital of Luzhou Medical College, Luzhou 646000, Sichuan Province, China
Correspondence to: Tian-Jun Wu, Department of Gastroenterology, Affiliated Hospital of Luzhou Medical College, Luzhou 646000, Sichuan Province, China. wutj21@163.com
Received: 2007-08-23 Revised: 2007-10-24
Abstract
Capsaicin has multiple pharmacological actions, and research has been centered on its effect on gastric motility. Most relevant studies have shown that low doses of capsaicin can accelerate, mediate, and high doses can inhibit gastric motility. The mechanism of action of capsaicin on gastric motility may involve vanilloid receptor subtype 1 (VR1), substance P, acetylcholine, neurokinin A, ghrelin and calcium ions. Capsaicin has promise as a new drug for gastric motility disorders.
Key Words: Capsaicin; Gastric motility; Mechanism of action
Wu TJ, Peng Y. Effect and mechanism of action of capsaicin on gastric motility. Shijie Huaren Xiaohua Zazhi 2007; 15(31): 3315-3319
摘要
辣椒素(capsaicin, CAP)药理作用广泛, 其对胃动力的影响已引起消化学者的关注. 多数研究认为小剂量的CAP可促进胃动力, 一定剂量范围的CAP可调节胃动力, 而大剂量CAP对胃动力可能有抑制作用. CAP对胃动力的作用机制可能与CAP受体(vanilloid receptor subtype 1, VR1)、P物质(SP)、乙酰胆碱、神经激肽A、生长激素释放肽和钙离子等有关. CAP可能成为一种有前景的胃动力新药.
关键词: 辣椒素; 胃动力; 机制
吴天军, 彭燕. 辣椒素对胃动力的影响及其机制. 世界华人消化杂志 2007;15(31):3315-3319
0 引言
胃肠动力疾病、功能性胃肠病是近年来导致消化疾病谱变化的主要因素, 此两类疾病在病因、发病机制、治疗等方面有许多相似之处, 关键环节均在于胃肠动力障碍[1-5]. 目前临床上改善胃肠动力的药物很少, 且作用尚不理想, 对胃肠动力疾病、功能性胃肠病的治疗面临新的挑战[6-9]. 辣椒素(capsaicin, CAP)对胃肠动力的作用已受到越来越多的关注[9-12], 本文就CAP对胃动力的研究进展进行综述.
1 CAP和CAP受体 ......
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