食管鳞癌组织中S100A4和MMP2蛋白表达与临床病理学特征的关系

http://www.100md.com 2007年11月8日 郑献召, 李珊珊, 轩小燕, 李 娜, 王 丰

关键词：食管鳞癌;S100A4蛋白;基质金属蛋白酶2;免疫组织化学技术,郑献召,李珊珊,轩小燕,李娜,王丰,通讯作者:,ExpressionofS100A4andmatrixmetalloproteinase2andtheircorrel

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     郑献召, 李珊珊, 轩小燕, 李娜, 王丰, 郑州大学第一附属医院病理科 河南省肿瘤病理重点实验室 河南省郑州市 450052

    河南省科技攻关基金资助项目, No. 072102310042

    通讯作者: 李珊珊, 450052, 河南省郑州市二七区建设东路1号, 郑州大学第一附属医院病理科, 河南省肿瘤病理重点实验室. lsspath@yahoo.com.cn

    电话: 0371-61550369

    收稿日期: 2007-06-06 修回日期: 2007-10-09

    Expression of S100A4 and matrix metalloproteinase 2 and their correlations with clinicopathological features in esophageal squamous cell carcinoma

    Xian-Zhao Zheng, Shan-Shan Li, Xiao-Yan Xuan, Na Li, Feng Wang

    Xian-Zhao Zheng, Shan-Shan Li, Xiao-Yan Xuan, Na Li, Feng Wang, Department of Pathology, the First Affiliated Hospital of Zhengzhou University, Key Laboratory of Tumor Pathology of He’nan Province, Zhengzhou 450052, He’nan Province, China

    Supported by: the Key Science and Technology Program of He’nan Province, No. 072102310042

    Correspondence to: Professor Shan-Shan Li, Department of Pathology, the First Affiliated Hospital of Zhengzhou University, Key Laboratory of Tumor Pathology of He’nan Province, 1 Jianshe East Road, 27 District, Zhengzhou 450052, He’nan Province, China. lsspath@yahoo.com.cn

    Received: 2007-06-06 Revised: 2007-10-09

    Abstract

    AIM: To investigate the expression of S100A4 and matrix metalloproteinase 2 (MMP-2) in esophageal squamous cell carcinoma and adjacent normal mucosa, and their correlation with clinicopathological features.

    METHODS: SP immunohistochemistry was used to detect the expression of S100A4 and MMP2 proteins in 100 cases of esophageal squamous cell carcinoma and adjacent normal mucosa.

    RESULTS: The positive rates of S100A4 and MMP2 protein expression were 52.00% and 67.00%, respectively, in esophageal squamous cell carcinoma, while only 26.00% and 31.00% in normal mucosa. The positive rates of S100A4 and MMP2 protein expression in esophageal squamous cell carcinoma were significantly higher than those in normal mucosa (P < 0.01). The expression of S100A4 and MMP2 protein was significantly associated with differentiation, depth of tumor invasion and lymph node metastasis (P < 0 ......

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