二步法大鼠原位全小肠移植模型的建立与改进
小肠移植;动物模型;原位移植;异位移植,朱亮,李幼生,黎介寿,通讯作者:,Establishmentoftwo-steporthotopicsmallintestinaltransplantationinrats,LiangZhu,You-ShengL
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朱亮, 大连医科大学生理教研室 辽宁省大连市 116027
李幼生, 黎介寿, 南京军区南京总医院全军普外科研究所 江苏省南京市 210002
朱亮, 讲师, 主要从事肠黏膜的损伤和保护, 器官移植和小肠移植方面的研究.
江苏省医学领军人才资助课题, No. 200710
辽宁省教育厅青年基金资助课题, No. 2004F088
国家973资助课题, No. 2003CB515502
通讯作者: 李幼生, 210002, 江苏省南京市, 南京军区南京总医院全军普外科研究所. zhuliang2001@nju.org.cn
电话: 025-86800137
收稿日期: 2007-07-12 修回日期: 2007-10-10
Establishment of two-step orthotopic small intestinal transplantation in rats
Liang Zhu, You-Sheng Li, Jie-Shou Li
Liang Zhu, Department of Physiology, Dalian Medical University, Dalian 116027, Liaoning Province, China
You-Sheng Li, Jie-Shou Li, Research Institute of General Surgery, Nanjing PLA General Hospital, Nanjing 210002, Jiangsu Province, China
Supported by: Outstanding Medical Academic Leader Program of Jiangsu Province, No. 200710; Science Fund for Young Scholars of Liaoning Province Department of Education, No. 2004F088; Major State Basic Research Development Program of China (973 Program), No. 2003CB515502
Correspondence to: You-Sheng Li, Research Institute of General Surgery, Nanjing PLA General Hospital, Nanjing 210002, Jiangsu Province, China. zhuliang2001@nju.org.cn
Received: 2007-07-12 Revised: 2007-10-10
Abstract
AIM: To establish a simple and stable model of orthotopic small intestinal transplantation in rats that minimizes mortality.
METHODS: The graft removed en bloc consisted of the entire small intestine, portal vein and donor aortic segment, along with the superior mesenteric artery. The graft was perfused in situ and the gut lumen was irrigated during the operation. Revascularization was accomplished by end-to-side anastomosis of the graft aortic segment to the prepared recipient aorta, and by the formation of a cuff anastomosis between the donor portal vein and the recipient left renal vein. In the first part of the two-stage procedure, the distal end of the graft was anastomosed to the side of the distal ileum, and the proximal end was fixed to the abdominal wall ......
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