非幽门螺杆菌非NSAID药物相关性溃疡
幽门螺杆菌;非甾体类抗炎药;消化性溃疡,张小晋,张小晋,通讯作者:,PepticulcerdiseasenotrelatedtoHelicobacterpyloriornon-steroidalanti-inflammatorydrugs,Xiao-J
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张小晋, 北京积水潭医院消化内科 北京市 100035
张小晋, 主任医师, 中国医科大学毕业, 主要从事消化内科, 专于胃肠疾病、肝病及内窥镜诊治.
通讯作者: 张小晋, 100035, 北京西城区新街口东街31号, 北京积水潭医院. zhangxiaojin1030@yahoo.com.cn
电话: 010-58517188
收稿日期: 2007-05-18 修回日期: 2007-08-26
Peptic ulcer disease not related to Helicobacter pylori or non-steroidal anti-inflammatory drugs
Xiao-Jin Zhang
Xiao-Jin Zhang, Department of Gastroenterology, Jishuitan Hospital, Beijing 100035, China
Correspondence to: Xiao-Jin Zhang, Beijing Jishuitan Hospital, 31 Xinjiekou East Street, Xicheng District, Beijing 100035, China. zhangxiaojin1030@yahoo.com.cn
Received: 2007-05-18 Revised: 2007-08-26
Abstract
Helicobacter pylori infection and non-steroidal anti-inflammatory drugs (NSAIDs) are widely accepted as the most important factors in the pathogenesis of peptic ulcers. However, the proportion of H pylori-negative peptic ulcers without intake of NSAIDs appears to have increased in recent years. The reason is partly related to a decreased prevalence ofH pylori among the population and more effective eradication of the bacterium, and it is also related to the defense measures for NSAIDs. The etiological factors involved in peptic ulcer disease not caused byH pylori or NSAIDs include altered acid secretion, abnormal gastric emptying, defective mucosal defense mechanisms, psychological stress, smoking, genetic predisposition and other chronic diseases. The main therapeutic measures include anti-secretory drugs and mucosal protectants.
Key Words: Helicobacter pylori; Non-steroid anti-inflammatory drugs; Peptic ulcer
Zhang XJ. Peptic ulcer disease not related to Helicobacter pylori or non-steroidal anti-inflammatory drugs. Shijie Huaren Xiaohua Zazhi 2007; 15(32): 3357-3359
摘要
幽门螺旋杆菌(H pylori)和非甾体类抗炎药(NSAIDs)已被公认为消化性溃疡的两个最主要的病因. 近年来, 越来越多的临床证据表明, 非H pylori和非NSAID溃疡的发生比例正在逐渐增加. 这可能与H pylori感染率的降低以及临床规范的根除H pylori治疗有关, 同时也与使用NSAIDs时注意防范其对胃肠道的损害有关 ......
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