大鼠30%小体积肝移植模型三种切肝方法的比较
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姚爱华, 浦立勇, 李相成, 姜 超, 马跃峰, 刘现忠, 仲跻魏, 王学浩
肝移植;小体积;大鼠;肝切除,姚爱华,浦立勇,李相成,姜超,马跃峰,刘现忠,仲跻魏,王学浩,姚爱华,通讯作者:,Differentmethodsofliverloberesectionforaratmodelof30%small-for-sizeli
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姚爱华, 浦立勇, 李相成, 姜超, 马跃峰, 刘现忠, 仲跻魏, 王学浩, 南京医科大学第一附属医院肝脏移植中心 江苏省南京市 210029
姚爱华, 1999年上海医科大学毕业, 2007年南京医科大学普外科博士, 主治医师, 主要从事肝脏移植, 活体肝移植术后损伤与再生、移植免疫等方面研究.
国家自然科学基金资助项目, No. 30671992
通讯作者: 王学浩, 210029, 江苏省南京市广州路300号, 南京医科大学第一附属医院肝脏移植中心, 中国活体肝脏移植研究所. wangxuehao1941@hotmail.com
电话: 025-83718836-6450 传真: 025-83672106
收稿日期: 2007-06-16 修回日期: 2007-09-30
Different methods of liver lobe resection for a rat model of 30% small-for-size liver transplantation
Ai-Hua Yao, Li-Yong Pu, Xiang-Cheng Li, Chao Jiang, Yue-Feng Ma, Xian-Zhong Liu, Ji-Wei Zhong, Xue-Hao Wang
Ai-Hua Yao, Li-Yong Pu, Xiang-Cheng Li, Chao Jiang, Yue-Feng Ma, Xian-Zhong Liu, Ji-Wei Zhong, Xue-Hao Wang, Liver Transplantation Center, Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Pro-vince, China
Supported by: National Natural Science Foundation of China, No. 30671992
Correspondence to: Prof. Xue-Hao Wang, Liver Transplantation Center, the Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029, Jiangsu Province, China. wangxuehao1941@hotmail.com
Received: 2007-06-16 Revised: 2007-09-30
Abstract
AIM: To explore an effective and viable way to establish a 30% small-for-size liver transplantation model in rats.
METHODS: Animals were divided into the following groups: groupⅠ(n = 28), 30% liver transplantation using a median lobe graft; group Ⅱ(n = 15), 30% liver transplantation using right lobe and right median lobe graft; and group Ⅲ (n = 36), 30% liver transplantation using a median lobe graft, with an improved technique of lobe resection. Male Lewis rats were used as donors and recipients, and the grafts were implanted according to Kamada’s two-cuff method. Seven-day survival and technical complications, including bleeding, IVC or portal vein stricture, and bile leakage, were compared between the groups. ......
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