IκB激酶家族新成员: IKKε
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曾 朋, 邓 欢, 刘亮明
IKKε;caspase;凋亡,IκB激酶家族新成员:IKKε,曾朋,邓欢,刘亮明,通讯作者:,NewmemberoftheIκBkinases:IKKε,PengZeng,HuanDeng,Liang-MingLiu,Supportedby:,Correspondenceto:,Recei
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曾朋, 武警江西省总队医院外一科 江西省南昌市 330001
邓欢,刘亮明, 南昌大学第二附属医院消化内科 江西省南昌市 330006
国家自然科学基金资助项目, No. 30660066
通讯作者: 刘亮明, 330006, 江西省南昌市民德路1号, 南昌大学第二附属医院消化科. liuliangming@x263.net
电话: 0791-6801253
收稿日期: 2007-07-24 修回日期: 2007-10-25
New member of the IκB kinases: IKKε
Peng Zeng, Huan Deng, Liang-Ming Liu
Peng Zeng, First Department of Surgery, Jiangxi Provincial Corps Hospital, Chinese People’s Armed Police Forces, Nanchang 330001, Jiangxi Province, China
Huan Deng, Liang-Ming Liu, Department of Gastroenterology, Second Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China
Supported by: National Natural Science Foundation of China, No. 30660066
Correspondence to: Liang-Ming Liu, Department of Gastroenterology, Second Affiliated Hospital of Nanchang University, 1 Minde Road, Nanchang 330006, Jiangxi Province, China. liuliangming@x263.net
Received: 2007-07-24 Revised: 2007-10-25
Abstract
IκB kinases (IKKs) are vital components of the nuclear factor-κB signaling pathway, which play an important role in innate immune and inflammation responses. The newest member of the IKKs is IKKε, which has similar functions to IKKα/β/γ and can act as a regulator of caspases by interacting with IAPs. Therefore, IKKs are a determinant of IAP level, and establish the threshold of activity required for the execution of non-apoptotic caspase functions.
Key Words: IKKε; caspase; Apoptosis
Zeng P, Deng H, Liu LM. New member of the IκB kinases: IKKε. Shijie Huaren Xiaohua Zazhi 2007; 15(33): 3524-3526
摘要
IκB激酶家族(IκB kinases, IKKs)是NF-κB信号途径最为重要的成员之一, 已发现其在先天性免疫以及炎症反应的调节中发挥关键作用. 除IKKα/β/γ之外, 作为IKKs的最新成员, IKKε不仅具有与IKKα/β/γ类似的作用, 而且最近的研究数据证实IKKε还能通过凋亡蛋白抑制物(inhibitor of apoptosis proteins, IAPs)调节caspases的活性, 参加caspases的凋亡和非凋亡依赖性信号途径 ......
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