丹参对重症急性胰腺炎大鼠腹腔器官血流的影响
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宋应平, 王成果, 鲁建国
急性胰腺炎;丹参;血流动力学;大鼠;多普勒超声,宋应平,王成果,鲁建国,通讯作者:,EffectsofSalviaemiltiorrhizaeonthesplanchnicbloodflowinratswithsevereacutepancreatit
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宋应平, 张掖医学高等专科学校基础部解剖学教研室 甘肃省张掖市 734000
王成果, 鲁建国, 中国人民解放军第四军医大学唐都医院普通外科 陕西省西安市 710032
通讯作者: 宋应平, 734000, 甘肃省张掖市甘州区西环路6号, 张掖医学高等专科学校基础部解剖学教研室. heatzl@sohu.com
电话: 0936-8232401 传真: 0936-8232401
收稿日期: 2007-08-29 修回日期: 2007-10-25
Effects of Salviae miltiorrhizae on the splanchnic blood flow in rats with severe acute pancreatitis
Ying-Ping Song, Cheng-Guo Wang, Jian-Guo Lu
Ying-Ping Song, Department of Anatomy, School of Basic Medicine, Zhangye Medical College, Zhangye 734000, Gansu Province, China
Cheng-Guo Wang, Jian-Guo Lu, Department of General Surgery, Tangdu Hospital, the Fourth Military Medical University, Xi’an 710032, Shaanxi Province, China
Correspondence to: Dr. Ying-Ping Song, Department of Anatomy, School of Basic Medicine, Zhangye Medical College, 6 Xihuan Road, Zhangye 734000, Gansu Province, China. heatzl@sohu.com
Received: 2007-08-29 Revised: 2007-10-25
Abstract
AIM: To observe the effects of Salviae mil-tiorrhizae (SM) on the splanchnic blood flow in rats with severe acute pancreatitis (SAP), and to elucidate the underlying mechanism.
METHODS: Thirty-two rats were randomly divided into SM group (n = 16) and SAP group (n = 16). Jejunotomy was performed in all. The SM group received indomethacin and the SAP group received saline. Another 8 normal rats were used as controls. At 12 and 24 hours after the induction of SAP, 8 rats in each group were sacrificed. Serum amylase was measured. The regional pancreatic blood flow was measured by Doppler ultrasound. The blood flow in the portal vein, spleen artery and superior mesenteric artery was also measured.
RESULTS: The levels of serum amylase at 12 and 24 hours after the induction of SAP were lower in the SM group than in the SAP group (8091.2 ± 1574.9 vs 15 142.8 ± 2900.5, 8312.5 ± 981.1 vs 16 987.1 ± 1584.6, P < 0.01). The regional pancreatic blood flow, and the blood flow in the portal vein, spleen artery and superiormesenteric artery were decreased significantly in the SAP and SM groups compared with the control group (P < 0 ......
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