VEGF/VEGFR2信号转导通路在抗肿瘤血管生成中的作用
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杨 军, 陈明清, 董 坚
血管内皮生长因子,血管内皮生长因子受体信号通路;抗肿瘤血管生成,杨军,陈明清,董坚,通讯作者:,Progressinanti-tumorangiogenesisresearchwithVEGF,VEGFR2pathwayasatarget
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杨军, 陈明清, 董坚, 昆明医学院第一附属医院 云南省昆明市 650032
云南省自然科学基金资助课题, No. 2005C0073M
昆明医学院创新群体基金资助课题, No. KMC2005DG01
通讯作者: 陈明清, 650032, 云南省昆明市西昌路295号, 昆明医学院第一附属医院肿瘤科. yougjen@yahoo.com.cn
电话: 0871-5361621 传真: 0871-5361621
收稿日期: 2007-08-13 修回日期: 2007-10-25
Progress in anti-tumor angiogenesis research with VEGF/VEGFR2 pathway as a target
Jun Yang, Ming-Qing Chen, Jian Dong
Jun Yang, Ming-Qing Chen, Jian Dong, the First Affiliated Hospital of Kunming Medical College, Kunming 650032, Yunnan Province, China
Supported by: the Natural Science Fund of Yunnan Province, No. 2005C0073M and the Inaugurate Colony Research Fund of Kunming Medical College, No. KMC2005DG01
Correspondence to: Dr. Ming-Qing Chen, Department of Oncology, the First Affiliated Hospital of Kunming Medical College, 295 Xichang Road, Kunming 650032, Yunnan Province, China. yougjen@yahoo.com.cn
Received: 2007-08-13 Revised: 2007-10-25
Abstract
The strategy of inhibiting angiogenesis by targeting tumor vascular endothelial cells, thereby blocking the blood supply to tumors, has become a hot topic in the field of anti-tumor growth and metastasis. The VEGF/VEGFR2 pathway plays a central role in tumor vasculature. Blocking it may achieve the purpose of inhibiting the growth and metastasis of cancer. This paper reviews the progress in studies of the VEGF/VEGFR2 signaling pathway in terms of anti-tumor growth and metastasis.
Key Words: Vascular endothelial growth factor/Vascular endothelial growth factor recepor 2 pathway; Anti-tumor angiogenesis
Yang J, Chen MQ, Dong J. Progress in anti-tumor angiogenesis research with VEGF/VEGFR2 pathway as a target. Shijie Huaren Xiaohua Zazhi 2007; 15(34): 3611-3616
摘要
以肿瘤血管内皮细胞为靶点抑制肿瘤血管生成从而阻断肿瘤血液供应已成为当前抗肿瘤生长和转移的研究热点. 其中, VEGF/VEGFR2信号转导通路在肿瘤周围血管生成起主要作用. 阻断该信号通路, 能够抑制实体瘤的生长和转移. 本文就VEGF/VEGFR2信号通路在抗肿瘤生长和转移中的研究进展作一概述.
关键词: 血管内皮生长因子/血管内皮生长因子受体信号通路; 抗肿瘤血管生成 ......
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