胰腺肿瘤标志物的研究进展
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王 伟, 张飞雄, 李兆申
胰腺炎;肿瘤标志物,王伟,李兆申,张飞雄,通讯作者:,Progressinresearchofpancreatictumormarkers,WeiWang,Zhao-ShenLi,Fei-XiongZhang,Correspondenceto:,Received:
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王伟, 李兆申, 中国人民解放军第二军医大学附属长海医院消化内科 上海市 200433
张飞雄, 宁夏医学院附属医院消化内科 宁夏回族自治区银川市 750004
通讯作者: 李兆申, 200433, 上海市长海路174号, 中国人民解放军第二军医大学附属长海医院消化内科. zhsli@81890.net
电话: 021-25070552
收稿日期: 2007-06-30 修回日期: 2007-11-20
Progress in research of pancreatic tumor markers
Wei Wang, Fei-Xiong Zhang, Zhao-Shen Li
Wei Wang, Zhao-Shen Li, Department of Gastroentero-logy, Changhai Hospital Affiliated to the Second Military Medical University, Shanghai 200433, China
Fei-Xiong Zhang, Department of Gastroenterology, the Affiliated Hospital of Ningxia Medical College, Yinchuan 750004, Ningxia Hui zu Autonomous Region, China
Correspondence to: Zhao-Shen Li, Department of Gastroenterology, Changhai Hospital Affiliated to the Second Military Medical University, 174 Changhai Road, Shanghai 200433, China. zhsli@81890.net
Received: 2007-06-30 Revised: 2007-11-20
Abstract
Pancreatic carcinoma is an almost uniformly lethal disease of humans and is associated with the lowest survival rate for any solid cancer, with only 5% of patients surviving 5 years after the diagnosis of pancreatic cancer. However, few effective methods can detect this kind of cancer at its early stage. The term “tumor marker” has been defined as “a naturally occurring molecule that is measured in serum or plasma, or other body fluids or in tissue extracts or in paraffin-embedded tissue to identify the presence of cancer, to assess patient prognosis, or to monitor a patient’s response to therapy with the overall goal of improving the clinical management of the patient.” The greatest limitation of most studies of serum markers is that they fail to limit their analyses to patients with small, potentially curable pancreatic cancers. Therefore, it appears to be particularly urgent to explore new markers and establish novel diagnostic methods so as to achieve sufficient sensitivity and specificity. We discuss the advantages and disadvantages of different pancreatic tumor markers in improving the the diagnosis and treatment of pancreatic carcinoma ......
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