鲜壁虎不同部位提取液对小鼠H22肝癌体内外抑制作用
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杨丽华, 杨金霞, 王学美, 富 宏, 刘庚信
壁虎;抗肝癌作用;MTT法,杨丽华,杨金霞,王学美,富宏,刘庚信,通讯作者:,Anti-tumoreffectsoffreshextractsfromdifferentpartsofgechoonmouseH22hepatocellularcar
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杨丽华, 杨金霞, 王学美, 富宏, 刘庚信, 北京大学第一医院中西医结合研究室 北京市 100034
国家自然科学基金资助项目, No. 30472137
国家中医药管理局资助项目, No. 04-05ZP04
通讯作者: 王学美, 100034, 北京市西城区西什库大街8号, 北京大学第一医院中西医结合研究室. wangxuemei64@sohu.com
电话: 010-66551122-3053 传真: 010-66551328
收稿日期: 2007-09-10 修回日期: 2007-10-30
Anti-tumor effects of fresh extracts from different parts of gecho on mouse H22 hepatocellular carcinoma in vivo and in vitro
Ying-Qiu Huang
Ying-Qiu Huang,Department of Gastroenterology, General Hospital of Benxi Steel & Iron (Group) Co. Benxi 117000, Liaoning Province, China
Correspondence to:Ying-Qiu Huang, Department of Gastroenterology, General Hospital of Benxi Steel & Iron (Group) Co., 29 Renmin Road, Pingshan District, Benxi 117000, Liaoning Province, China. huangyingqiu_bx@126.com
Received:2007-05-14 Revised:2007-08-13
Abstract
AIM: To research the anti-proliferation effects of fresh extracts from different parts of gecko on cultured H22 hepatoma cells in vitro, and the tumor-inhibiting effects of these extracts on mice with transplanted H22 tumors in vivo, to identify the active components.
METHODS: MTT assay was used to evaluate the anti-proliferation effects of fresh extracts from different parts of gecko, such as the skin, head, muscle and bone, internal organs, tail and whole gecko, on cultured H22 hepatoma cells in vitro. Transplanted H22 tumor-bearing mice were used as a model for observing the anti-tumor effects of extracts from gecko internal organs, geckos without internal organs and whole geckos. The mice were divided into two groups and given each type of extract, with one group receiving a high dose and the other a low dose.
RESULTS: High doses of gecko internal organ extract revealed an obvious anti-proliferation effect on H22 cells in the in vitro experiment, the inhibition rate was 61.6%. Compared with other extracts, the inhibitory effect was significant (P < 0 ......
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