热休克预处理对大鼠肠缺血-再灌注损伤的保护效应
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莫燕娜, 王丹妹, 吉丽敏, 翁 阳, 何 佟, 陈世民
肠;缺血-再灌注;热休克预处理;caspase-3;白细胞凋亡;免疫印迹法,莫燕娜,王丹妹,吉丽敏,何佟,陈世民,翁阳,莫燕娜,通讯作者:,Protectiveeffectofpreviousheatshocktreatmentonintesti
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莫燕娜, 王丹妹, 吉丽敏, 何佟, 陈世民, 海南医学院机能学实验室 海南省海口市 571101
翁阳, 海南医学院病理学教研室 海南省海口市 571101
莫燕娜, 副教授, 主要从事缺血再灌注损伤发生机制和防治方法研究.
海南省自然科学基金资助项目, No. 30625
海南省普通高校优秀中青年教师科研与教学奖励基金资助项目, No. 琼教高[2000]36
通讯作者: 莫燕娜, 571101, 海南省海口市, 城西学院路海南医学院机能学实验室. yannamo18@126.com
电话: 0898-66895765
收稿日期: 2007-07-13 修回日期: 2007-11-02
Protective effect of previous heat shock treatment on intestinal injury following mesenteric ischemia/reperfusion in rats
Yan-Na Mo, Dan-Mei Wang, Li-Min Ji, Yang Weng, Tong He, Shi-Min Chen
Yan-Na Mo, Dan-Mei Wang, Li-Min Ji, Tong He, Shi-Min Chen, Department of Functional Laboratory, Hainan Medical College, Haikou 571101, Hainan Province, China
Yang Weng, Department of Pathology, Hainan Medical College, Haikou 571101, Hainan Province, China
Supported by: the Natural Science Foundation of Hainan Province, No. 30625 and the Award Funding of Research and Teaching Special for Outstanding Young and Middle-age Teachers of Hainan, No. [2000]36
Correspondence to: Yan-Na Mo, Department of Functional Laboratory, Hainan Medical College, Chengxi Xueyuan Road, Haikou 571101, Hainan Province, China. yannamo18@126.com
Received: 2007-07-13 Revised: 2007-11-02
Abstract
AIM: To investigate the protective effect of previous heat shock treatment on intestinal injury following mesenteric ischemia/reperfusion (I/R).
METHODS: Forty adult male Sprague-Dawley rats were divided into 4 groups (10 in each group): control group (CTRL), ischemia/reperfusion group (IR), previous heat shock treatment group (42C) and ischemia reperfusion group (42IR). The expression of HSP72 was examined in the small intestinal mucosa using Western blotting, and pathological changes in the ileal mucosal tissue were evaluated by microscopy. The apoptosis of intestinal mucosal epithelial cells was examined by terminal deoxylnucleotidyl transferase mediated-dUTP nick end labeling (TUNEL) ......
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