急性胰腺炎大鼠肺组织与肺泡巨噬细胞早期生长反应基因-1的表达

http://www.100md.com 邹 树, 田伏洲, 汤礼军, 黎冬暄, 汪 涛, 石 力

鍏抽敭璇嶏細 急性胰腺炎;早期生长反应基因-1;肺损伤;弹性蛋白酶;肺泡巨噬细胞;细胞外信号调节激酶;逆转录聚合酶链反应,邹树,田伏洲,汤礼军,黎冬暄,汪涛,石力,邹树,通讯作者:,Earlygrowthresponsefactor1

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     邹树, 田伏洲, 汤礼军, 黎冬暄, 汪涛, 石力, 中国人民解放军成都军区总医院全军普通外科中心 四川省成都市 610083

    邹树, 博士, 主治医师, 主要从事胰腺与胆道疾病研究.

    通讯作者: 田伏洲, 610083, 四川省成都市, 中国人民解放军成都军区总医院全军普通外科中心 . tfz30061@yahoo.com.cn

    电话: 028-86570351 传真: 0411-83631284

    收稿日期: 2007-07-09 修回日期: 2007-10-18

    Early growth response factor 1 expression in rat lungs and alveolar macrophages during acute pancreatitis

    Shu Zou, Fu-Zhou Tian, Li-Jun Tang, Dong-Xuan Li, Tao Wang, Li Shi

    Shu Zou, Fu-Zhou Tian, Li-Jun Tang, Dong-Xuan Li, Tao Wang, Li Shi, Department of General Surgery Center, General Hospital of Chengdu Command of Chinese PLA, Chengdu 610083, Sichuan Province, China

    Correspondence to: Professor Fu-Zhou Tian, Department of General Surgery Center, General Hospital of Chengdu Command of Chinese PLA, Chengdu 610083, Sichuan Province, China. tfz30061@yahoo.com.cn

    Received: 2007-07-09 Revised: 2007-10-18

    Abstract

    AIM: To investigate the possible role of early growth response factor 1 (EGR-1) in a rat model of lung injury complicated by taurocholate sodium-induced acute pancreatitis.

    METHODS: Forty male Wistar rats were randomly divided into four groups. Normal saline was injected into the common bile duct (CBD) of rats in group A, and taurocholate sodium was injected into the CBD of rats in groups B, C and D. Three hours after injection, all animals were sacrificed, and blood, pancreas and lungs were harvested. Serum levels of tumor necrosis factor (TNF)-α and interleukin (IL)-1β were measured. Pathological scoring of the pancreas was analyzed, and the pulmonary wet to dry weight ratio was measured. Immunohistochemical staining of EGR-1 on lung paraffin sections was observed and assayed semi-quantitatively. Immunocytochemical staining of EGR-1 of AMs was observed and assayed semi-quantitatively, and the concentration of TNF-α and IL-1β in culture fluid was measured. AMs were divided into four groups and treated with elastase as above ......

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