肝移植患者术中凝血功能的变化及影响因素

http://www.100md.com 马焕先, 董家鸿, 段伟东, 陈永亮

閸忔娊鏁拠宥忕窗亲体肝移植;原位肝移植;凝血功能,马焕先,董家鸿,段伟东,陈永亮,马焕先,通讯作者:,Changeinbloodcoagulationandcorrelativeinfluentialfactorsinlivertransplantation,Huan-

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     马焕先, 董家鸿, 段伟东, 陈永亮, 中国人民解放军总医院肝胆外科 北京市 100853

    马焕先, 在读博士, 医师, 主要从事肝移植围手术期处理的研究.

    通讯作者: 董家鸿, 100853, 北京市海淀区复兴路28号, 中国人民解放军总医院肝胆外科. dongjh301@163.com

    电话: 010-66939817

    收稿日期: 2007-06-01 修回日期: 2007-09-19

    Change in blood coagulation and correlative influential factors in liver transplantation

    Huan-Xian Ma, Jia-Hong Dong, Wei-Dong Duan, Yong-Liang Chen

    Huan-Xian Ma, Jia-Hong Dong, Wei-Dong Duan, Yong-Liang Chen, Institute of Hepatobiliary Surgery, General Hospital of Chinese PLA, Beijing 100853, China

    Correspondence to: Jia-Hong Dong, Institute of Hepatobiliary Surgery, General Hospital of Chinese PLA, 28 Fuxing Road, Haidian District, Beijing 100853,China. dongjh301@163.com

    Received: 2007-06-01 Revised: 2007-09-19

    Abstract

    AIM: To investigate intraoperative blood coagulation variation and correlative influential factors in liver transplantation.

    METHODS: Twenty-nine cases undergoing orthotopic liver transplantation from cadaveric livers from 2006-06 to 2007-05 and 15 cases undergoing living-donor liver transplantation in the same period were studied retrospectively. We assessed prothrombin time (PT), activated partial thromboplastin time (APPT), international normalizing ratio (INR), fibrinogen (FIB), platelet (PLT), hemoglobin concentration(Hb),albumin (ALB) and total carbon dioxide (TCO2) during the pro-operation period, dissection period, anhepatic period, early and late neohepatic period, respectively. Changes of every value reflecting blood coagulation function and acid-base metabolism condition were observed in all groups, and fluctuation patterns of all values were studied between periods and groups. Perioperative influential factors were also analyzed. In addition, we compared values of living-donor liver transplantation with orthotopic liver transplantation from cadaveric livers in the same period and studied their correlations ......

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