肝癌组织DNA-PKcs过量表达及其靶向siRNA分子的抗增殖作用
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余子建, 徐勤枝, 周丽君, 隋建丽, 张士猛, 安 静, 王 豫, 周平坤
肝癌;DNA-PKcs;c-Myc;组织芯片;小干扰RNA;细胞增殖;放射增敏,余子建,徐勤枝,隋建丽,张士猛,安静,王豫,周平坤,周丽君,通讯作者:,Over-expressionofDNA-PKcsinhepatocar
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余子建, 南华大学附属第一医院普外科 湖南省衡阳市 421001
徐勤枝, 隋建丽, 张士猛, 安静, 王豫, 周平坤, 军事医学科学院放射与辐射医学研究所放射毒理与肿瘤研究室 北京市 100850
周丽君, 中国人民解放军海军总医院中心实验室 北京市 100037
余子建, 主任医师, 教授, 主要从事临床肝胆外科和实验肿瘤研究.
国家自然科学基金资助项目, No. 30500267, 30672429
北京市自然科学基金资助项目, No. 7072057
湖南省卫生厅基金课题资助项目, No. C2005038
通讯作者: 周平坤, 100850, 北京市, 军事医学科学院放射与辐射医学研究所放射毒理与肿瘤研究室. zhoupk@nic.bmi.ac.cn
电话: 010-66931217
收稿日期: 2007-06-13 修回日期: 2007-11-25
Over-expression of DNA-PKcs in hepatocarcinoma tissues and the antiproliferative effect mediated by down-regulating its expression with siRNA
Zi-Jian Yu, Qin-Zhi Xu, Li-Jun Zhou, Jian-Li Sui, Shi-Meng Zhang, Jing An, Yu Wang, Ping-Kun Zhou
Zi-Jian Yu, Department of General Surgery, the First Affiliated Hospital of Nanhua University, Hengyang 421001, Hunan Province, China
Qin-Zhi Xu, Jian-Li Sui, Shi-Meng Zhang, Jing An, Yu Wang, Ping-Kun Zhou, Department of Radiation Toxicology and Oncology, Beijing Institute of Radiation Medicine, Beijing 100850, China
Li-Jun Zhou, Center of Clinical Laboratory, Navy General Hospital of Chinese PLA, Beijing 100037, China
Supported by: National Natural Science Foundation of China, No. 30500267, 30672429, and the Natural Science Foundation of Beijing City, No. 7072057, and the Hunan Provincial Bureau of Health, No. C2005038
Correspondence to: Ping-Kun Zhou, Department of Radiation Toxicology and Oncology, Beijing Institute of Radiation Medicine, Beijing 100850, China. zhoupk@nic.bmi.ac.cn
Received: 2007-06-13 Revised: 2007-11-25
Abstract
AIM: To characterize the difference in DNA-dependent protein kinase catalytic subunit (DNA-PKcs) expression between hepatocarcinoma tissues and non-tumor liver tissues, and to understand the biological significance of the altered expression of DNA-PKcs in cancer cells.
METHODS: DNA-PKcs expression was examined in 86 specimens of hepatocarcinoma and hepatic cholangiocarcinoma by immunohistochemistry analysis on tissue-arrays and ordinary pathological tissue slices ......
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