蛋白质组学技术在大肠癌肿瘤标志物研究中的应用
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刘伟杰, 秦环龙
蛋白质组学;大肠癌;标志物,刘伟杰,秦环龙,通讯作者:,Applicationofproteomictechniquesinresearchonbiomarkersforcolorectalcancer,Wei-JieLiu,Huan-LongQin,Supportedby:,Correspon
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刘伟杰, 秦环龙, 上海交通大学附属第六人民医院普外科 上海市 200233
上海市科委基金资助项目, No. 05DJ14010
通讯作者: 秦环龙, 200233, 上海交通大学附属第六人民医院普外科. hlqin@sjtu.edu.cn
电话: 021-64942226 传真: 021-64701361
收稿日期: 2007-08-06 修回日期: 2007-12-06
Application of proteomic techniques in research on biomarkers for colorectal cancer
Wei-Jie Liu, Huan-Long Qin
Wei-Jie Liu, Huan-Long Qin, Department of General Surgery, Sixth People’s Hospital of Shanghai Jiaotong University, Shanghai 200233, China
Supported by: Shanghai Science and Technology Commission Funded Projects, No. 05DJ14010
Correspondence to: Huan-Long Qin, Department of General Surgery, Sixth People’s Hospital of Shanghai Jiaotong University, Shanghai 200233, China. hlqin@sjtu.edu.cn
Received: 2007-08-06 Revised: 2007-12-06
Abstract
Colorectal cancer (CRC) is one of the most common cancers in humans, and is often diagnosed at an intermediate or late stage with poor prognosis. Early detection may improve prognosis greatly. Current biomarkers (such as CEA and CA-199) lack sensitivity and specificity for general population screening. Hence, there is a great need for new biomarkers for early detection of CRC. Recently, proteomics has rapidly developed and been applied to every field in the life sciences, especially tumor research. Proteomic techniques give us the possibility to discover early diagnostic and prognostic biomarkers for CRC. In this study, the utilization of proteomics techniques in research on biomarkers for CRC is reviewed briefly.
Key Words: Proteomics; Colorectal cancer; Biomarker
Liu WJ, Qin HL. Application of proteomic techniques in research on biomarkers for colorectal cancer. Shijie Huaren Xiaohua Zazhi 2007; 15(36): 3836-3841
摘要
大肠癌是人类常见的肿瘤之一, 往往被诊断出时已是中晚期, 预后较差. 因此, 早期诊断是治疗的关键, 能明显改善预后. 虽然当前血清CEA和CA-199等的检测已被广泛应用于大肠癌的筛选, 但其缺乏特异性和敏感性, 这就需要进一步寻找新的标志物. 近年来, 蛋白质组学的发展已深入到生命科学的各个领域, 尤其应用于肿瘤研究方面, 这就为我们发现新的大肠癌标志物提供了崭新的途径 ......
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