药物载体系统的研究进展
杨绮华
(广东汕头大学医学院第一附属医院药剂科，汕头 515041)
[摘要] 本文综述了药物载体系统在近些年的新发展，特别是对脂质体、脂肪粒子和毫微囊三种载体系统的制剂和药效学等方面的研究进行了论述，为研究开发载体制剂提供参考。
[关键词] 药物载体；脂质体；脂肪粒子；毫微囊
【作者简介】杨绮华(1950-)，女，副主任药师，研究方向：医院药学、药物制剂。电话：0754-8258290—3102。
[参考文献]
1 王建新，张志荣。固体脂质纳米粒的研究进展[J]。中国药学杂志，2001；36(2)：73-76。
2 Balasubrumanian-SV , Straubinger-RM et al . Taxol-lipid interactions : taxol-dependent effectson thephsical properties ofmodel membranes [J]. Biochemistry,1994;33(30):8941-7.
3 Burke-TG , Gao-X , et al ; Stabilization of topotecan in low Ph liposomes composed of distearoy phosphatidylcholine[J] . J-Pharm-Sci . 1994;83(7):967-9
4 Choudhari-KB , Labhasetioar-U , et al ; Liposomes as a carrier for oral administration of insulin : effect of formulation factors[J] . J-Microencapsal,1994 May-Jun :11(3):319-25.
5 Michelson AM, Stadtman E, Boon P, et al. Decreased skin superoxide dismutase activity by a single exposure of ultraviolet radiation was reduced by liposomal superoxide petreatment〔J〕. J Dermatol,1996,96(13):1376-1383.
6 Kedar-E, Rukowski-Y et al. Delivery of cytokines by liposomes. I.preparation andcharacterization of interleukin-2 encapsulated in long circulating sterically stalbilizedliposomes[J]. J-Im-munother-Emphasis-Tumor-Immunol. 1994 Jul ; 16(1):47-59.
7 Yerashalmi-M, Margalit-R, et al; Bioaadhesive collagen-modified liosomes: molecular and cellular level studieson themonolayers[J]. Arch-Biochem-Biophys. 1994 Jan 3;1189(1):13-20.
8 Yerashalmi-M, Margalit-R; Molecular and cellular studies of hzaluronic acid-modifid liposomes as bioadhesive carrier for topical drug dellvery in wound healing[J]. Arch-Biochem-biophys. 1994 Sep; 313(2):267-73.
9 Ohmukai O. Lipo-NSAID preparation[J]. Adv Drug Deliv Rev, 1996;20(2/3): 203~207., http://www.100md.com
(广东汕头大学医学院第一附属医院药剂科，汕头 515041)
[摘要] 本文综述了药物载体系统在近些年的新发展，特别是对脂质体、脂肪粒子和毫微囊三种载体系统的制剂和药效学等方面的研究进行了论述，为研究开发载体制剂提供参考。
[关键词] 药物载体；脂质体；脂肪粒子；毫微囊
【作者简介】杨绮华(1950-)，女，副主任药师，研究方向：医院药学、药物制剂。电话：0754-8258290—3102。
[参考文献]
1 王建新，张志荣。固体脂质纳米粒的研究进展[J]。中国药学杂志，2001；36(2)：73-76。
2 Balasubrumanian-SV , Straubinger-RM et al . Taxol-lipid interactions : taxol-dependent effectson thephsical properties ofmodel membranes [J]. Biochemistry,1994;33(30):8941-7.
3 Burke-TG , Gao-X , et al ; Stabilization of topotecan in low Ph liposomes composed of distearoy phosphatidylcholine[J] . J-Pharm-Sci . 1994;83(7):967-9
4 Choudhari-KB , Labhasetioar-U , et al ; Liposomes as a carrier for oral administration of insulin : effect of formulation factors[J] . J-Microencapsal,1994 May-Jun :11(3):319-25.
5 Michelson AM, Stadtman E, Boon P, et al. Decreased skin superoxide dismutase activity by a single exposure of ultraviolet radiation was reduced by liposomal superoxide petreatment〔J〕. J Dermatol,1996,96(13):1376-1383.
6 Kedar-E, Rukowski-Y et al. Delivery of cytokines by liposomes. I.preparation andcharacterization of interleukin-2 encapsulated in long circulating sterically stalbilizedliposomes[J]. J-Im-munother-Emphasis-Tumor-Immunol. 1994 Jul ; 16(1):47-59.
7 Yerashalmi-M, Margalit-R, et al; Bioaadhesive collagen-modified liosomes: molecular and cellular level studieson themonolayers[J]. Arch-Biochem-Biophys. 1994 Jan 3;1189(1):13-20.
8 Yerashalmi-M, Margalit-R; Molecular and cellular studies of hzaluronic acid-modifid liposomes as bioadhesive carrier for topical drug dellvery in wound healing[J]. Arch-Biochem-biophys. 1994 Sep; 313(2):267-73.
9 Ohmukai O. Lipo-NSAID preparation[J]. Adv Drug Deliv Rev, 1996;20(2/3): 203~207., http://www.100md.com