抗Tac单抗的药效学、药代动力学及临床疗效

http://www.100md.com 2002年5月25日 新药网

     杨惠娣，曹惠明

    [摘要] 重组人源化单克隆抗体抗Tac单抗是一种免疫抑制剂，特异性抑制T细胞介导的免疫反应，用于减少肾移植患者发生的急性排异反应。抗Tac单抗单用或联合用药均显示较好的临床疗效及耐受性。

    [关键词] 抗Tac单抗；药效学；药代动力学；临床疗效

    Pharmacodynamic, Pharmacological and Clinical use of Zenapax

    Yang HuiDi , Chao HuiMing

    [Abstract] Zenapax, recombinant humanized IgG anti-Tac monoclonal antibody, is a new immuno-suppressive drug. The compound selectively targets activated T-lymphocytes, which are known to play a pivotal role to reduce acute organ rejection in patients receiving renal transplants. Anti-Tac monoclonal antibody displayed a satisfactory clinical effect and tolerance.

    [Key words] Zenapax ; Pharmacodynatics ; Pharmacological ; Clinical use

    [参考文献]

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    [6]Ekberg H, et al. 抗Tac单抗 reduces the incidence of acute rejection episodes and improves patient survival following renal transplantation. Transplantation Proc, 1999;31:267-8

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