苏拉明抗肿瘤作用研究进展

http://www.100md.com 2002年5月25日 新药网

     张居馨

    ( 天津医药科学研究所 生物技术室 天津300070 )

    [摘要] 苏拉明是一个用于治疗锥虫和/或盘尾丝虫感染的抗寄生虫药。近些年研究发现苏拉明对肿瘤细胞增殖、浸润、转移等有一定的抑制作用。体内外研究证实苏拉明对多种恶性肿瘤有抗肿瘤活性。本文综述了近二十年来苏拉明抗肿瘤研究的进展，简述了苏拉明的理化特性、吸收分布，重点叙述了苏拉明抗肿瘤作用机制以及临床应用。

    [关键词] 苏拉明；抗肿瘤作用机制；临床应用

    THE NEW PROGRESS OF THE RESEARCH ON THE ANTITUMOR EFFECTS OF SURAMIN

    Zhang Ju-xin

    Laboratory of Biotechnique, Tianjin Medicine & Pharmaceutical Institute

    Tianjin ( 300070 )

    [Abstract] Suramin has long been used to treat human trypanosomiasis and onchocerciasis, but since the recent years has received attention as an antitumor drug which has some inhibitory effect on the proliferation ,invasion and metastasis of some malignant tumor cells in vitro and in vivo. The new progress of the research on the antitumor effect of suramin was reviewed, the physiochemical characteristics, and its pharmacokinetics were described, the antitumor effect and clinical application of this drug were emphasized.

    [Key words] suramin ; antitumor effect; clinical application.

    [作者简介] 张居馨(1949—)，女，研究员，从事药理、免疫、细胞学研究。联系电话：(022)23358826—3019，Email: tjimps@publicltpt.tj 。

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