塞曲司特的合成
何拥军, 谢敏浩, 邹霈, 刘娅灵, 罗世能
(江苏省原子医学研究所, 无锡214063)
[摘要] 目的：合成塞曲司特。方法：以庚二酸单乙酯为原料，经酰氯化、傅克酰化、还原、水解、缩合及氧化反应合成塞曲司特。结果：塞曲司特的总产率为50.7%。结论：本方法条件温和，操作简单，适合于工业化。
[关键词] 塞曲司特；合成；缩合
[中图分类号] R974.3 [文献标识码] B [文章编号] 1003-3734(2001)
Synthesis of seratrodrast
HE Yong-jun, XIE Min-hao, ZOU Pei , LIU Ya-ling, LUO Shi-neng
(Jiangsu Institute of Nuclear Medicine, WuXi 214063,China)
[Abstact] Objective:To synthesize seratrodrast. Methods and Results:Through acylation, Friedel-Crafts reaction, reduction , hydrolysis , condensation and oxidation,the titled compound was prepared with a total yield of 50.7%. Conclusion:This synthetic procedure is mild,convenient,simple and suit able to be industralized.
[Key words]seratrodrast；synthesis；condensation
[作者简介] 何拥军(1973- ), 男，助理研究员。从事新药科研工作。联系电话：(0510)5514482-3501。
[参考文献]
[1] AA-2414.Drugs Future[J], 1990，15(8)：783-785.
[2] Shiraishi M, Kato K, Terao S, et al. Quinones. 4 Novel Eicosanoid Antagonists:Synthesis and Pharmacological Evaluation[J].J Med Chem, 1989，32(9)：2214-21., 百拇医药
(江苏省原子医学研究所, 无锡214063)
[摘要] 目的：合成塞曲司特。方法：以庚二酸单乙酯为原料，经酰氯化、傅克酰化、还原、水解、缩合及氧化反应合成塞曲司特。结果：塞曲司特的总产率为50.7%。结论：本方法条件温和，操作简单，适合于工业化。
[关键词] 塞曲司特；合成；缩合
[中图分类号] R974.3 [文献标识码] B [文章编号] 1003-3734(2001)
Synthesis of seratrodrast
HE Yong-jun, XIE Min-hao, ZOU Pei , LIU Ya-ling, LUO Shi-neng
(Jiangsu Institute of Nuclear Medicine, WuXi 214063,China)
[Abstact] Objective:To synthesize seratrodrast. Methods and Results:Through acylation, Friedel-Crafts reaction, reduction , hydrolysis , condensation and oxidation,the titled compound was prepared with a total yield of 50.7%. Conclusion:This synthetic procedure is mild,convenient,simple and suit able to be industralized.
[Key words]seratrodrast；synthesis；condensation
[作者简介] 何拥军(1973- ), 男，助理研究员。从事新药科研工作。联系电话：(0510)5514482-3501。
[参考文献]
[1] AA-2414.Drugs Future[J], 1990，15(8)：783-785.
[2] Shiraishi M, Kato K, Terao S, et al. Quinones. 4 Novel Eicosanoid Antagonists:Synthesis and Pharmacological Evaluation[J].J Med Chem, 1989，32(9)：2214-21., 百拇医药