华裔科学家许田在果蝇中揭示肿瘤广泛浸润的遗传机理
编者按：肿瘤广泛浸润发展是肿瘤致死性的主要原因，但其遗传背景一直不明朗。过去一些研究揭示，突变一些metastasis suppressor genes 能抑制肿瘤细胞的metastasis特性。许田这篇报道则揭示了使不浸润的肿瘤细胞变成浸润性肿瘤细胞的关键因子RasV12 。
A Genetic Screen in Drosophila for Metastatic Behavior
Raymond A. Pagliarini and Tian Xu
Science, Vol. 302, Issue 5648, 1227-1231, November 14, 2003
A genetic screen was designed in Drosophila to interrogate its genome for mutations sufficient to cause noninvasive tumors of the eye disc to invade neighboring or distant tissues. We found that cooperation between oncogenic RasV12 expression and inactivation of any one of a number of genes affecting cell polarity leads to metastatic behavior, including basement membrane degradation, loss of E-cadherin expression, migration, invasion, and secondary tumor formation. Inactivation of these cell polarity genes cannot drive metastatic behavior alone or in combination with other tumor-initiating alterations. These findings suggest that the oncogenic background of tissues makes a distinct contribution toward metastatic development.
Abstract of this Article
PDF Version of this Article
Supporting Online Material, http://www.100md.com(生物谷)
A Genetic Screen in Drosophila for Metastatic Behavior
Raymond A. Pagliarini and Tian Xu
Science, Vol. 302, Issue 5648, 1227-1231, November 14, 2003
A genetic screen was designed in Drosophila to interrogate its genome for mutations sufficient to cause noninvasive tumors of the eye disc to invade neighboring or distant tissues. We found that cooperation between oncogenic RasV12 expression and inactivation of any one of a number of genes affecting cell polarity leads to metastatic behavior, including basement membrane degradation, loss of E-cadherin expression, migration, invasion, and secondary tumor formation. Inactivation of these cell polarity genes cannot drive metastatic behavior alone or in combination with other tumor-initiating alterations. These findings suggest that the oncogenic background of tissues makes a distinct contribution toward metastatic development.
Abstract of this Article
PDF Version of this Article
Supporting Online Material, http://www.100md.com(生物谷)