周东 裘明德 关玉娟 李龄 2004-8-8 15:24:46 中国神经免疫学和神经病学杂志 1999年第1期第6卷 论 著

    摘要 目的 探讨一氧化氮(NO)在脑外伤急性期的变化及意义。方法 用Griess试剂测定脑脊液中NO含量。结果 脑外伤急性期NO峰值高于对照组(t=2.834,P<0.01)；重伤组NO动态监测时，其峰值(10.872±9.231)μmol/L出现于伤后24 h内，48～72 h再次升高为(6.577±5.720)μmol/L,而轻伤组仅出现于48 h内，为(6.470±5.886)μmol/L;预后不良组NO峰值高于良好组(t=2.313,P<0.05)。结论 脑外伤急性期NO有不同程度的升高，伤情越重，升高越明显，预后也越差。NO与临床指标的结合将提高对颅脑损伤的程度和预后判断的准确率。

    中图号 R651.102 R651.107

    Changes and Significance of Nitric Oxide in Patients with Brain Trauma at Acute Stage

    Zhou Dong Qiu Mingde Guan Yujuan Li Ling

    (Department of Neurosurgery, Tongji Hospital, Tongji Medical University, Wuhan 430030)

    Objective To investigate the changes and significance of nitric oxide (NO) following brain trauma at acute stage.Methods The value of NO was determined by Griess reagent in cerebrospinal fluid of patients with acute brain-injury and was analyzed by combining with clinical index.Results The peak value of NO was significantly higher in the brain-injured group than that in the control group, P<0.01; in severe group, NO peak value appeared within 24 hours, declined within 24-48 hours, and increased again from 48 to 72 hours; but in mild group, NO peak value appeared within 48 hours; the value of NO was higher in the poor prognostic cases than that in the good ones, P<0.05.Conclusions NO has different increases following acute brain injury, the severer the traumatic severity, the higher NO increases, and the poorer the outcome becomes. When NO level is combined with clinical index, the accuracy of judging the severity of brain injury and the outcome, prognosis will be improved. ......