脑动静脉畸形血液动力学的临床检测与理论分析
北京宣武医院神经外科 (100053)
【摘要】
目的：根据脑动静脉畸形(arteriovenous malformation, AVM)血液动力学参数的临床实测与理论分析结果，探讨其变化的原因。方法：对37例脑AVM (病例组)和同期15例非心脑血管病(对照组)患者的大脑前、中和后动脉的阻力、压力、流速、流量、直径和血管壁面切应力进行测量(或)测算及统计分析，并以电学和优化原理进行推导和解释。
结果：病例组参与脑AVM供血的动脉与未参与供血的动脉相比，流速加快(大脑前、中和后动脉中的临床检测统计均值的t检验T值与P值依次分别为与、与和与，下同)，流量增大(与、与和与)，压力降低(与、与和与)；病例组参与脑AVM供血的动脉与对照组的同名动脉相比：阻力降低(与、与和与)，直径增粗(与、与和与)，血管壁面切应力趋向守恒(与、与和与)；上述变化可由电学原理推导证明和优化理论解释。
, 百拇医药
结论： 动静脉直接交通是脑AVM低阻力的结构基础，并导致AVM血管高流速和流量，而参与脑AVM供血的动脉直径增粗和血管壁面切应力趋向守恒是遵循能耗优化普遍性原理的适应性改变。
【关键词】脑动静脉畸形 血液动力学 参数测量 电学 优化原理
Hemodynamics of brain arteriovenous malformation:clinical
measurement and theoretical analysis
WANG Daming, LING Feng, SUN Shujin, YAN Zongyi, ZHANG Yang. Department of Neurosurgery (WANG D, LING F, ZHANG Y ), Beijing Hospital, Beijing 100730; Department of Mechanical and Engineering Science (SUN S, YANG Z), Beijing University, Beijing 100871
, 百拇医药
【Abstract】Objective：To report the hemodynamic parameter values of brain arteriovenous malformation (AVM) obtainning by clinical measurement and theoretical deduction, and to explore the cause of those changes. Methods：The parameter data including vessel resistance, pressure, flow velocity, flow rate, diameter and vessel wall shear stress at the A1, M1 and P1 segment respective of the anterior, middle and posterior cerebral artery (ACA-A1, MCA-M1 and PCA-P1) were measured or calculated to the brain AVM group (a series of 37 consecutive cases) and normal control group (15 contemporaneous cases without any cardio- and brain vascular disease), all the above data were analyzed statistically and farther deducing or verifying were done with the principle of electricity and minimum work. Results：The statistical analysis on the data of those arteries supplied AVM verse un-supplied or verse normal control indicated that vessel resistance and blood pressure were decreased, flow velocity and flow rate increased, arterial diameter enhanced, but vessel wall shear stress trending conservational, and those changes can be deduce and explain from the formula of electricity and minimum work. Conclusions：The arteriovenous shunt in brain AVM is its low resistance cause in angio-architecture, which leads to low pressure and high flow velocity and flow rate, but the diameter widering and vessel wall shear stress trending conservational in those arteries supplied AVM are the accommodation follows the general principle of minimum work.
【Key words】 Brain arteriovenous malformation; Hemodynamics; Parameter measurement; Electricity; Minimum work, http://www.100md.com(王大明 凌锋 孙树津 严宗毅 张洋)
【摘要】
目的：根据脑动静脉畸形(arteriovenous malformation, AVM)血液动力学参数的临床实测与理论分析结果，探讨其变化的原因。方法：对37例脑AVM (病例组)和同期15例非心脑血管病(对照组)患者的大脑前、中和后动脉的阻力、压力、流速、流量、直径和血管壁面切应力进行测量(或)测算及统计分析，并以电学和优化原理进行推导和解释。
结果：病例组参与脑AVM供血的动脉与未参与供血的动脉相比，流速加快(大脑前、中和后动脉中的临床检测统计均值的t检验T值与P值依次分别为与、与和与，下同)，流量增大(与、与和与)，压力降低(与、与和与)；病例组参与脑AVM供血的动脉与对照组的同名动脉相比：阻力降低(与、与和与)，直径增粗(与、与和与)，血管壁面切应力趋向守恒(与、与和与)；上述变化可由电学原理推导证明和优化理论解释。
, 百拇医药
结论： 动静脉直接交通是脑AVM低阻力的结构基础，并导致AVM血管高流速和流量，而参与脑AVM供血的动脉直径增粗和血管壁面切应力趋向守恒是遵循能耗优化普遍性原理的适应性改变。
【关键词】脑动静脉畸形 血液动力学 参数测量 电学 优化原理
Hemodynamics of brain arteriovenous malformation:clinical
measurement and theoretical analysis
WANG Daming, LING Feng, SUN Shujin, YAN Zongyi, ZHANG Yang. Department of Neurosurgery (WANG D, LING F, ZHANG Y ), Beijing Hospital, Beijing 100730; Department of Mechanical and Engineering Science (SUN S, YANG Z), Beijing University, Beijing 100871
, 百拇医药
【Abstract】Objective：To report the hemodynamic parameter values of brain arteriovenous malformation (AVM) obtainning by clinical measurement and theoretical deduction, and to explore the cause of those changes. Methods：The parameter data including vessel resistance, pressure, flow velocity, flow rate, diameter and vessel wall shear stress at the A1, M1 and P1 segment respective of the anterior, middle and posterior cerebral artery (ACA-A1, MCA-M1 and PCA-P1) were measured or calculated to the brain AVM group (a series of 37 consecutive cases) and normal control group (15 contemporaneous cases without any cardio- and brain vascular disease), all the above data were analyzed statistically and farther deducing or verifying were done with the principle of electricity and minimum work. Results：The statistical analysis on the data of those arteries supplied AVM verse un-supplied or verse normal control indicated that vessel resistance and blood pressure were decreased, flow velocity and flow rate increased, arterial diameter enhanced, but vessel wall shear stress trending conservational, and those changes can be deduce and explain from the formula of electricity and minimum work. Conclusions：The arteriovenous shunt in brain AVM is its low resistance cause in angio-architecture, which leads to low pressure and high flow velocity and flow rate, but the diameter widering and vessel wall shear stress trending conservational in those arteries supplied AVM are the accommodation follows the general principle of minimum work.
【Key words】 Brain arteriovenous malformation; Hemodynamics; Parameter measurement; Electricity; Minimum work, http://www.100md.com(王大明 凌锋 孙树津 严宗毅 张洋)