Chin Crit Care Med,September 2004,Vol.16,No9
PAGE:513-514
ACC/AHA/ESC treatment guideline fo suberventricular arrhythmia
SHEN Hong , GUO Ji-hong
Department of Emergency, General Hospital of PLA, Beijing 100853, China
PAGE:515-517
Anitmicrobial therapy in severe sepsis and septic shock
QIU Hai-bo, GUO Feng-mei, ZHENG Rui-qiang
, 百拇医药
ICU,Zhongda Hospital, South-east University, Nanjing 210009, Jiangsu, China
PAGE:518-519
Current status and prospect of critical care medicine in Western Pacific countries and regions: summary of 13th Western Pacific Congress on Critical Care Medicine
MA Peng-lin
ICU, General Hospital of PLA, BeiJing 100037, China
PAGE:520-522
, 百拇医药
Prognostic significance of early acute renal failure in patients with cardiogenic shock after acute myocardial infarction
WU Hai-yun, WANG Shi-wen, ZHAO Yu-sheng, XU Qiang, ZHU Shu.
Institute of Geriatric Cardiology, General Hospital of PLA, Beijing 100853, China
Objective To investigate the relationship between early developed acute renal failure and the prognosis of patients with cardiogenic shock after myocardial infarction. Methods All patients who were consecutively to the General Hospital of PLA from 1993 to 2003 admitted with the diagnosis of acute myocardial infarction or unstable angina in the state of cardiogenic shock were enrolled. In-hospital mortality was compared between patients with and without early (<24 hours after onset of shock) developed acute renal failure. Multivariate logistic regression analysis was performed to assess the impact of acute renal failure on the prognosis of these patients. Results Fifty-one (30%) of 172 patients developed acute renal failure within 24 hours after the onset of shock. In-hospital mortality in patients with and without acute renal failure were 90% (46/51 cases) and 56% (68/121 cases), respectively. Multivariate logistic regression analysis identified acute renal failure as an independent predictor of mortality (odds ratio=6.5; 95% confidenceinterval: 2.5-18.0; P<0.001). Conclusion Acute renal failure is common in patients with cardiogenic shock and strongly associated with in-hospital mortality.
, 百拇医药
PAGE:523-526
Effects of angiotensin-(1-7) on remodeling of myocardial collagen network in pressure-overloaded rats
SHE Jian-gui, HUANG Yi-yi, MA Hong, HE Xiao-hong, LIAO Xin-xue, WANG Li-chun, ZHOU Jian-zhong.
Department of Cardiology, First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, Guangdong, China
Objective To investigate the effects of angiotensin-(1-7) on remodeling of myocardial collagen network in pressure-overloaded rats. Methods A rat model of pressure-overloaded heart was induced by constriction of abdominal aorta. Seventy-five male Sprague Dawley rats were randomized to sham-operated group, model control group and angiotensin-(1-7) group. The rats of the latter two groups were treated with intravenous infusion of either angiotensin-(1-7) (25 μg·kg-1·h-1) or saline after operation. Ratio of left ventricular weight to body weight(LVW/BW) and myocardial collagen volume fraction(CVF) were determined at 1 and 4 weeks after operation. And types Ⅰ and Ⅲ collagen mRNA expression were assessed with reverse transcription-polymerase chain reaction(RT-PCR). Results At 1 week after the operation, types Ⅰ and Ⅲ collagen mRNA expressions of the left ventricular myocardium in model group and angiotensin-(1-7) group were increased significantly compared with those in sham-operated group. But those in angiotensin-(1-7) group were significantly lower than that in model group. At 4 weeks after the operation, LVW/BW and CVF were increased significantly in model group and angiotension-(1-7) group compared with those in sham-operated group, but those in angiotension-(1-7)group were significantly lower than that of model group. Conclusion Angiotensin-(1-7) can attenuateremodeling of myocardial collagen network in pressure-overloaded rats.
, http://www.100md.com
PAGE:526
Effect of high-dose Fulsix on obstinate heart failure complicated by acute myocardial infarctrion: a case report
CHENG Yun-you
Pingyi TCM Hospital of Shandong 273300, China
PAGE:527-529
Changes in tissue plasminogen activator and plasminogen activator inhibitor during administration of nitroglycerine into internal thoracic artery in dogs with acute myocardial ischemia
, 百拇医药
WU Xin, WANG Cao-feng, SHENG Jing, ZHU Jian.
Affiliated the 9 th People's Hospital, Shanghai Second Medical University Shanghai 200011, China
Objective To study the changes in tissue plasminogen activator(t-PA) and plasminogen activator inhibitor(PAI) in a model of acute myocardial infarction reproduced in the dog with administration of nitroglycerin into internal thoracic artery under pressure. Methods Sixty healthy cross-breed dogs were randomly divided into experimental and control group with 30 dogs in each group. The animal model of acute myocardial ischemia was reproduced by ligating the left anterior descending coronary artery. Internal thoracic artery in the experimental group was ligated, and a tube was introduced into the proximal end. Nitroglycerine was infused under pressure into the internal thoracic artery in experimental group. The drug was given intravenously in control group. t-PA and PAI were measured before anterior coronary artery ligation and at 0.5, 2 and 6 hours after cononary artery ligation. Results The t-PA levels in two groups were increased at 0.5 hour after coronary artery ligation, and gradually declined in control group, while no obvious change was found in experimental group. There was significant difference between experimental group and control group at 6 hours after coronary artery ligation(P<0.05). PAI levels were increased after coronary artery ligation, peaking at 6 and 2 hours after coronary artery ligation in both groups. Significant difference in PAI level was observed between two groups at 6 hours after coronary artery ligation(P<0.05). Conclusion Introduction of nitroglycerine through internal thoracic artery under pressure is effective to accelerate release of t-PA from the endothelium while inhibit secretion of PAI, therefore it is useful to modulatethe balance of fibrinolysis
, 百拇医药
PAGE:530-532
Protection of renal function during interventional diagnostic or therapeutic procedures in coronary heart disease patients complicated by chronic renal insufficiency
HAN Ya-ling, ZANG Hong-yun, JING Quan-min,WANG Shou-li, WANG Dong-mei, WANG Zu-lu.
Department of Cardiology, General Hospital of Shenyang Command, Shenyang 110016, Liaoning, China
, 百拇医药 Objective To evaluate the safety and efficacy of protective measures for renal function during interventional procedures in patients with chronic renal insufficiency. Methods Changes in renal function in 90 patients of coronary artery disease with chronic renal insufficiency admitted from January 1994 to July 2002 during intervention perioperation were analyzed. These patients were divided into three groups: in group A patients underwent coronary angiography(SCA) with conventional peri-interventive treatment; in group B patients underwent SCA and treated with low dose dopamine plus saline hytration peri-interventively; in group C patients underwent percutaneous transluminal coronary angioplasty(PTCA) and stenting, and treated with low dose dopamine plus saline hytration during peri-interventively. Results Coronary intervention was successful in all patients of three groups. Contrast medium-associated nephropathy(CAN) was found in 28 patients after the procedures, and them 11 occurred in group A (36.7%), 5 in group 16.7%), and 12 in group C(40.0%), respectively. The incidence of CAN was highest in group C, and lowest in group B (P<0.01). All patients recovered and discharged after medical treatment, and no hemodialysis was necessary. Higher incidence of CAN was found in patients with congestiv heart failure than patients without heart failure(64.5%, 20/31 cases vs. 13.6%, 8/59 cases; P<0.01), and also higher incidence of CAN was found in diabetic patients than non-diabetic patients (42.6%, 23/54 cases vs. 13.9%, 5/36 cases; P<0.01). Conclusion The patients with coronary artery disease with chronic renal insufficiency are able to tolerate the interventiona procedures well with safety and ideal prognosis, if they are properly protected with dopamine and fluid during the procedure.
, 百拇医药
PAGE:533-535
Clinical study on changes of heme oxygenase-1 expression in patients with acute myocardial infarction
CHEN Song-ming, LI Yu-guang, WANG Dong-ming, LIN Ji-jin.
Department of Cardiology, First Affiliated Hospital of Medical College, Shantou University, Shantou 515041, Guangdong, China
Objective To investigate changes inheme oxygenase-1(HO-1) in patients with acute myocardial infarction. Methods Forty-five patients with acute myocardial infarction and 50 with coronary heart disease (diagnosed by coronary angiography) but without acute myocardial infarction were included in this study, and another 40 patients with normal coronary artery as controls. Levels of HO-1 protein expression in monocyte and lymphocyte isolated from the patients were determined by immunohistochemistry and Western blot. Computer picture analyzing system was also ture analyzing system was also used to measure levels of HO-1 protein expression. Results HO-1 protein expression was located in the cytoplasm. The levels of O-1 protein expression in patients with acute myocardial infarction were significantly higher than those without acute myocardial infarction (P<0.01). In addition, low levels of HO-1 protein expression were observed in patients with normal coronary artery. Conclusion There is a higher expression of HO-1 in patients with acute myocardial infarction, and a lower expression in patients with normal coronary artery.
, 百拇医药
PAGE:536-539
Association between serum matrix metalloproteinase-3 concentration and the promoter 5A/6A polymorphism in patients with coronary heart disease
GAO Bo, LI Zhong-cheng.
Tianjin Tianhe Hospital, Tianjin 300050, China
Objective To investigate the association between serum matrix metalloproteinase-3 (MMP-3) concentrations and the promoter 5A/6A polymorphism in patients with coronary heart disease (CHD). Methods The study enrolled 137 CHD patients and 106 control subjects without CHD. The diagnosis of both groups were confirmed by coronary artery angiography.One hundred and thirty-seven CHD patients were divided into acute myocardial infarction(AMI) group, unstable angina pectoris(UAP) group and stable angina(SA) group according to World Health Organization criteria. Serum concentration of MMP-3 was measured by enzyme linked immunoadsorbent assay(ELISA). MMP-3 promoter gene containing the 5A/6A polymorphism was amplified by polymerase chain reaction (PCR). PCR products were digested by Tth111Ⅰand then were separated by electrophoresis on agarose gel. Results The distribution of MMP-3 genotype was not significantly different between CHD patients and controls, so was it between AMI patients and controls. Serum MMP-3 level was significantly higher in AMI group than controls, UAP group and SA group((56.815±38.932)μg/L, (39.149±24.155)μg/L, (41.640±29.180)μg/L, (33.336±20.755)μg/L； P<0.01,P<0.05, P<0.01). Serum MMP-3 levels were not significantly different among genotypes and among controls, UAP and SA groups. No significantly differences in serum MMP-3 levels were found among patients with different numbers of coronary arteries that were involved in CHD. Conclusion No marked association could be found between 5A/6A polymorphism in MMP-3 gene and risk of CHD and AMI. Higher serum level of MMP-3 is strong associated with AMI, while not with number of coronary arteries that are involved in CHD. These data suggest that MMP-3 is a useful marker for AMI, and it might play an important role in the induction of disruption of atherosclerosis plaque.
, 百拇医药
PAGE:539
Experience in treatment of brain and heart embolism in the elderly
BAO Jian-zhou, ZHOU Bao-hua , DENG Chun-fang, LIU Xin-hua
The Dongying Second Hopsital, Shandong 300250, China
PAGE:540-543
Characteristics and therapeutic strategies of nosocomial pneumonia in postoperat
ive patients with acute hypertensive intracerebral hemorrhage
, http://www.100md.com
TONG Ying, ZHAN Ren-ya，SU Qun.
Department of Neurosurgery, First Affiliated Hospital, Medical College, Zhejiang University, Hangzhou 310003， Zhejiang, China
Objective To investigate the characteristics of postoperative nosocomial pneumonia in patients with acute hypertensive intracerebral hemorrhage after evacuation of hematoma and the strategies of prevention and treatment. Methods Retrospective analysis was performed on the clinical data of surgically treated patients with acute hypertensive intracerebral hemorrhage in the Department of Neurosurgery from 2000 to 2003. The patients were divided into a group who developed nosocomial pneumonia to compare with a group who did not. Sputum was cultured B and drug sensitivity of isolated bacteria was performed. Appropriate treatment measures were given according to clinical manifestations. Results In 112 post operative patients with acute hypertensive intracerebral hemorrhage, nosocomial pneumonia developed in 29 patients(25.89%), and 65.99% of microorganisms isolated from respiratory secretion was Gram-negative bacteria.The predominant bacteria were Pseudomonas aeruginosa and Staphylococcus aureus. The mortalitywas 34.48% (10/29 cases). The prognosis of patients with nosocomial pneumonia was worse than the controls(7.23%, 6/83 cases, P<0.01). Conclusion The preventive and therapeutic strategies for nosocomial pneumonia in postoperative patients with acute hypertens
, http://www.100md.com
ive intracerebral hemorrhage include reduction of risk-factors, surveillance of pathogens, rational use of antibiotics, respiratory and nutrition support, and so on
PAGE: 543
A case of thyrotoxic myopathy after cardiac operation
ZHANG Qing-xiang, ZHANG Xue-mei, LIU Jing-kui, LI Zong-xiao, KONG De-ping
Mudanjiang Cardiovascular Hospital, Heilongjiang 157011, China
, 百拇医药
PAGE: 544-546
Optimal time window for minimally invasive aspiration and drainage of the hematoma in patients with intracerebral hemorrhage
LIU Li-jun, XUE Zhan-cang, YANG Guo-qing, ZHANG
Xiu-ming. The First Municipal Hospital, Shijiazhuang 050011, Hebei, China
Objective To seek the optimal time window for minimally invasive aspiration and drainage of the hematoma in patients with intracerebral hemorrhage. Methods One hundred and twenty-six patients with intracerebral hemorrhage were divided into two groups in terms of the operation time window: ultra-early stage group(within 6 hours) and early stage group (6-24 hours). European stroke scale (ESS) score and Bartherl index(BI) were used to evaluate the improvement of neurological function. Results There were no significant differences between the two groups in ESS score, complications, and past medical history on hospital admission. Also no difference existed in the volume of hematoma in different regions of the brain between the two groups, including putamen thalamus and brain lobes. However, one month after the onset, mean ESS score was 64.76±7.12 and the mean BI was 66.39±7.23 in the ultra-early stage group (non-survivors were excluded), whereas in the early stage group, they were 59.21±8.63 and 61.91±8.31 (non-survivors were excluded too), respectively (both P<0.01). Three months after the mean BI was 79.46±13.29 in the ultra-super early stage group and 72.32±11.86in the early stage group, and the difference in the two groups was significant(P<0.01). Though surgery in the ultra-early stage gave better results than that in early stage, no marked difference in mortality was found between the two groups(P>0.05). Conclusion The aspiration and drainage of the hematoma should be done as early as possible(within 6 hours of the onset) provided that the patients are fit to undergo the surgery.
, 百拇医药
PAGE: 547-551
Analysis of causes of late mortality in liver transplant recipients
PAN Cheng,Ashok Jain△, John J. Fung△.
The Department of Transplantation Surgery, Tianjin First Central Hospital, Tianjin 300192, China;△Thomas E. Starzl Transplantation Institute, University of Pittsburgh, PA, 15213, USA
Objective To evaluate the cause of late mortality in liver transplant recipients, and to study the prevention and management of these complications. Methods Two thousand nine hundred and forty patients who underwent liver transplantation at University of Pittsburgh and survived more than 1 year between February 1981 and April 1998 were included in this study. Cause of death, and other relative factors were analyzed. Results The rate of death dramatically decreased from 20.4% to 1.9% during that 10 years(1981-1991). Eight hundred and seventeen patients who survived more than 1 year had died during the follow-up period. The causes of death were malignant tumor (20.7%), cardiovascular complication (11.4%), infection (11.3%), and respiratory system complications (9.4%). Following the change in the immunosuppression protocol (1981-1986 was cyclosporin-A, 1986-1990 was OKT3, 1991-1998 was FK506), the 1-year death rate, 5-year death rate, and 10-year death rate were constantly decreased postoperatively. Patients of 3-18-year old group had the lowest mortality rate, while that of 19-60-year old group had the highest mortality rate. The patients who received liver transplantation because hepatic carcinoma or fulminant hepatic failure had the highest mortality after the operation. Mortality of the patients who received liver transplantation because of alcoholic cirrhosis increased gradually year by year. Conclusion Malignant tumor, cardiovascular complication, infection and respiratory system complications are the most common causes of late mortality after liver transplantation. Early diagnosis and treatment can improve the survival rate.
, 百拇医药
PAGE: 551
Successful rescscitation of a case with respiratory and cardiac arrest for 20 minutes
CHEN Jiang
Department of Emergency, Shanxi Spaceflight Hospital, Xi'an 710025, China
PAGE: 552-555
Clinical study on the early nutrition support in postoperative patients with critical hypertensive intracerebral hemorrhage
, 百拇医药
ZHANG Jian-jun, DONG Wei-feng, GU Shui-jun, ZHANG Jun, XUAN Hong-fei, XIE Ren-long. Department of Neurosurgery, Xiaoshan First People's Hospital, Hangzhou 311201, Zhejiang, China
Objective To investigate the clinical significance of early nutritional support for patients with critical hypertensive intracerebral hemorrhage(HICH) in a critical condition after operation, and the rationale of different methods of nutritional support. Methods One hundred and seven HICH patients after operation with Glasgow coma score(GCS) 6-8 were randomly divided into three groups: early enteral nutrition(EEN) group(38 cases);early parenteral nutrition(EPN) group(35 cases),conventional treatment controls(34 cases). They were given different nutritionalsupports 48 hours after operation. Changes in nutritional parameters and the clinical complications in three groups after treatment were observed, and the treatment effects after 3 months were compared. Results At the end of first week after operation, nutrition parameters including albmin(ALb), hemoglobin(Hgb) in EEN and EPN groups were better than those in control group(P<0.05); at the end of second week, they were differences among three groups but without statistical significance (P>0.05). The complications were higher in EPN and control groups(P<0.05 or P<0.01). The outcome was assessed 3 months after the operation in term of activity of daily life(ADL), and the result was better in EEN group than that in EPN and control groups(P<0.005). Conclusion Postoperative HICH patients in critical condition could be benifited with EEN, and complications could bereduced with improved prognosis
, 百拇医药
PAGE: 556-557
Evaluation on the therapeutic effects of two methods of stereotactic CT-guided aspiration and drainage in acute intracerebral hemorrhage
WANG Guo-ping , LI Huai-yu, REN Ming-shan , YANG Yi, SUN Bai-song, ZHU Shou-zheng , WANG Yi-xin , ZHOU Qing-chao , ZHOU Ben-xiu
Department of neurology, Anhui Municipal Hospital, An'hui 230001, China
PAGE: 558-559
, http://www.100md.com
Clinical study of Nictinamide on patients with unstable Angina pectoris
ZHANG Su-rong LIU Ping CHEN Zhi-gang YUAN Yu LV Feng-hua ZHANG Yong-chun LI Hong-jun , HUANG Lu-li
Department of cariiovescular, First Affilated Hospital Xinxiang Medical College, Weihui 453100, Henan, China
PAGE: 560-561
The protective effect of zinc on myocardial ischemia/reperfusion jnjury in rabbits
, http://www.100md.com
SHEN Bing-ling, QIN Yi , YAN Li-qiu
Department of Pathophysiology, Tianjin Medical University
PAGE: 561
The application of Carbostent in emergency percutaneous coronary intervention(PCI)
GUAN-wei , LIU Xin-qiao, ZHAO Chun-yan , SHAO Lei , ZHENG Xiao-wen
The Tianjin Third Hospital, 300250, Tianjin, China
, 百拇医药
PAGE: 562-563
Expression of CD44V6 In colorectal carcinoma and its clinical significance
WANG Li-ping, WU Tie-feng, WANG Chun-tian
Department of Surgery, Affiliated Hospital of Chengda Medical College, Chengde 067000, Hebei, China
PAGE: 563
Gene expression of PTEN in human glioma
XU Xin-nv, WANG Jin-huan, LI Jun-yi, LIU Hong-sheng , LU Yi, QI Jian-bin
, http://www.100md.com
Key Laboratory, First Central Hospital, Tianjin 300192, China
PAGE: 564-565
Radical correction of severe teralogy of Fallot in 39 infants
WANG Jian-ming, WANG Zhen, LIU Su-ran, LU Zhi-kai , WANG Hai-ming, LIN Wei, TAO Shu-guang
Department of Cardiac surgery, Children Hospital, Hebei 050031, China
PAGE: 565
, 百拇医药
Application of magnesium sulfate in peri-operative treatment of acute amniotic embolism
ZHANG Ming-tu , LI Fang, Zhu Ming, XU Duo-jia, XU JUN , DU Guang-sheng
Department of Anesthesiology Jinhua Central Hospital, Jinhua 321000, China
PAGE: 566
Application of non-invasive hemodynamic monitoring on cor pulmonale patients under mechanical ventilation
, 百拇医药
WANG Bo , LU Zhong-yuan, SUN Ping
117th Hospital of PLA, Hanzhou 310013, China
PAGE: 567
The application of intraoperative autotransfusional technique in emergency operation with serious bleeding
ZHENG Xiang-de, FENG Qing, LIU Wen-hu , LI Shu-fang , WANG Xu , LI Zheng-qing Dazhou Central Hospital, Sichuan 635000, China
PAGE: 568-569
, 百拇医药
Clinical observation of blood adsorption and hemodialysis on severe burned pastients LIU Hui , ZHAO Qing , HOU Xiu-ni
Weihaiwei People's Hospital, Weihai 264200, China
PAGE: 569
Response of brachial artery flow to vasodilatory drugs in hypertensive patients
ZHANG Tie-mei, XU Xiu-ying
Department of Caridolog Tiantan Hospital, Beijing 100050, China
, http://www.100md.com
PAGE: 570-573
Inflammation and Acute Coronary Artery Syndrome
YANG Shen-li , LIU Hui-liang, HE Zuo-yun
Department of cardiology, The General Hospital of the people's Armed Police of Beijing 100039, China
PAGE: 573
The Fifty Examples’ soved Feeding of Breathing And Heart-beating Stopping
YANG Xiu-hui, ZHENG Fu-xia, LIU Hui-jie
, http://www.100md.com
Luohe Central Hospital, Henan 462000, China
PAGE: 574-576
Advance in treatment of nervous system disease with neural stem cells
ZHANG Zhi-ming , ZHAO Jing, ZHU Zhao-lin
Department of Neurosurgery, Tianhe Hospital, Tianjin 300050, China, 百拇医药
ACC/AHA/ESC treatment guideline fo suberventricular arrhythmia
SHEN Hong , GUO Ji-hong
Department of Emergency, General Hospital of PLA, Beijing 100853, China
PAGE:515-517
Anitmicrobial therapy in severe sepsis and septic shock
QIU Hai-bo, GUO Feng-mei, ZHENG Rui-qiang
, 百拇医药
ICU,Zhongda Hospital, South-east University, Nanjing 210009, Jiangsu, China
PAGE:518-519
Current status and prospect of critical care medicine in Western Pacific countries and regions: summary of 13th Western Pacific Congress on Critical Care Medicine
MA Peng-lin
ICU, General Hospital of PLA, BeiJing 100037, China
PAGE:520-522
, 百拇医药
Prognostic significance of early acute renal failure in patients with cardiogenic shock after acute myocardial infarction
WU Hai-yun, WANG Shi-wen, ZHAO Yu-sheng, XU Qiang, ZHU Shu.
Institute of Geriatric Cardiology, General Hospital of PLA, Beijing 100853, China
Objective To investigate the relationship between early developed acute renal failure and the prognosis of patients with cardiogenic shock after myocardial infarction. Methods All patients who were consecutively to the General Hospital of PLA from 1993 to 2003 admitted with the diagnosis of acute myocardial infarction or unstable angina in the state of cardiogenic shock were enrolled. In-hospital mortality was compared between patients with and without early (<24 hours after onset of shock) developed acute renal failure. Multivariate logistic regression analysis was performed to assess the impact of acute renal failure on the prognosis of these patients. Results Fifty-one (30%) of 172 patients developed acute renal failure within 24 hours after the onset of shock. In-hospital mortality in patients with and without acute renal failure were 90% (46/51 cases) and 56% (68/121 cases), respectively. Multivariate logistic regression analysis identified acute renal failure as an independent predictor of mortality (odds ratio=6.5; 95% confidenceinterval: 2.5-18.0; P<0.001). Conclusion Acute renal failure is common in patients with cardiogenic shock and strongly associated with in-hospital mortality.
, 百拇医药
PAGE:523-526
Effects of angiotensin-(1-7) on remodeling of myocardial collagen network in pressure-overloaded rats
SHE Jian-gui, HUANG Yi-yi, MA Hong, HE Xiao-hong, LIAO Xin-xue, WANG Li-chun, ZHOU Jian-zhong.
Department of Cardiology, First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, Guangdong, China
Objective To investigate the effects of angiotensin-(1-7) on remodeling of myocardial collagen network in pressure-overloaded rats. Methods A rat model of pressure-overloaded heart was induced by constriction of abdominal aorta. Seventy-five male Sprague Dawley rats were randomized to sham-operated group, model control group and angiotensin-(1-7) group. The rats of the latter two groups were treated with intravenous infusion of either angiotensin-(1-7) (25 μg·kg-1·h-1) or saline after operation. Ratio of left ventricular weight to body weight(LVW/BW) and myocardial collagen volume fraction(CVF) were determined at 1 and 4 weeks after operation. And types Ⅰ and Ⅲ collagen mRNA expression were assessed with reverse transcription-polymerase chain reaction(RT-PCR). Results At 1 week after the operation, types Ⅰ and Ⅲ collagen mRNA expressions of the left ventricular myocardium in model group and angiotensin-(1-7) group were increased significantly compared with those in sham-operated group. But those in angiotensin-(1-7) group were significantly lower than that in model group. At 4 weeks after the operation, LVW/BW and CVF were increased significantly in model group and angiotension-(1-7) group compared with those in sham-operated group, but those in angiotension-(1-7)group were significantly lower than that of model group. Conclusion Angiotensin-(1-7) can attenuateremodeling of myocardial collagen network in pressure-overloaded rats.
, http://www.100md.com
PAGE:526
Effect of high-dose Fulsix on obstinate heart failure complicated by acute myocardial infarctrion: a case report
CHENG Yun-you
Pingyi TCM Hospital of Shandong 273300, China
PAGE:527-529
Changes in tissue plasminogen activator and plasminogen activator inhibitor during administration of nitroglycerine into internal thoracic artery in dogs with acute myocardial ischemia
, 百拇医药
WU Xin, WANG Cao-feng, SHENG Jing, ZHU Jian.
Affiliated the 9 th People's Hospital, Shanghai Second Medical University Shanghai 200011, China
Objective To study the changes in tissue plasminogen activator(t-PA) and plasminogen activator inhibitor(PAI) in a model of acute myocardial infarction reproduced in the dog with administration of nitroglycerin into internal thoracic artery under pressure. Methods Sixty healthy cross-breed dogs were randomly divided into experimental and control group with 30 dogs in each group. The animal model of acute myocardial ischemia was reproduced by ligating the left anterior descending coronary artery. Internal thoracic artery in the experimental group was ligated, and a tube was introduced into the proximal end. Nitroglycerine was infused under pressure into the internal thoracic artery in experimental group. The drug was given intravenously in control group. t-PA and PAI were measured before anterior coronary artery ligation and at 0.5, 2 and 6 hours after cononary artery ligation. Results The t-PA levels in two groups were increased at 0.5 hour after coronary artery ligation, and gradually declined in control group, while no obvious change was found in experimental group. There was significant difference between experimental group and control group at 6 hours after coronary artery ligation(P<0.05). PAI levels were increased after coronary artery ligation, peaking at 6 and 2 hours after coronary artery ligation in both groups. Significant difference in PAI level was observed between two groups at 6 hours after coronary artery ligation(P<0.05). Conclusion Introduction of nitroglycerine through internal thoracic artery under pressure is effective to accelerate release of t-PA from the endothelium while inhibit secretion of PAI, therefore it is useful to modulatethe balance of fibrinolysis
, 百拇医药
PAGE:530-532
Protection of renal function during interventional diagnostic or therapeutic procedures in coronary heart disease patients complicated by chronic renal insufficiency
HAN Ya-ling, ZANG Hong-yun, JING Quan-min,WANG Shou-li, WANG Dong-mei, WANG Zu-lu.
Department of Cardiology, General Hospital of Shenyang Command, Shenyang 110016, Liaoning, China
, 百拇医药 Objective To evaluate the safety and efficacy of protective measures for renal function during interventional procedures in patients with chronic renal insufficiency. Methods Changes in renal function in 90 patients of coronary artery disease with chronic renal insufficiency admitted from January 1994 to July 2002 during intervention perioperation were analyzed. These patients were divided into three groups: in group A patients underwent coronary angiography(SCA) with conventional peri-interventive treatment; in group B patients underwent SCA and treated with low dose dopamine plus saline hytration peri-interventively; in group C patients underwent percutaneous transluminal coronary angioplasty(PTCA) and stenting, and treated with low dose dopamine plus saline hytration during peri-interventively. Results Coronary intervention was successful in all patients of three groups. Contrast medium-associated nephropathy(CAN) was found in 28 patients after the procedures, and them 11 occurred in group A (36.7%), 5 in group 16.7%), and 12 in group C(40.0%), respectively. The incidence of CAN was highest in group C, and lowest in group B (P<0.01). All patients recovered and discharged after medical treatment, and no hemodialysis was necessary. Higher incidence of CAN was found in patients with congestiv heart failure than patients without heart failure(64.5%, 20/31 cases vs. 13.6%, 8/59 cases; P<0.01), and also higher incidence of CAN was found in diabetic patients than non-diabetic patients (42.6%, 23/54 cases vs. 13.9%, 5/36 cases; P<0.01). Conclusion The patients with coronary artery disease with chronic renal insufficiency are able to tolerate the interventiona procedures well with safety and ideal prognosis, if they are properly protected with dopamine and fluid during the procedure.
, 百拇医药
PAGE:533-535
Clinical study on changes of heme oxygenase-1 expression in patients with acute myocardial infarction
CHEN Song-ming, LI Yu-guang, WANG Dong-ming, LIN Ji-jin.
Department of Cardiology, First Affiliated Hospital of Medical College, Shantou University, Shantou 515041, Guangdong, China
Objective To investigate changes inheme oxygenase-1(HO-1) in patients with acute myocardial infarction. Methods Forty-five patients with acute myocardial infarction and 50 with coronary heart disease (diagnosed by coronary angiography) but without acute myocardial infarction were included in this study, and another 40 patients with normal coronary artery as controls. Levels of HO-1 protein expression in monocyte and lymphocyte isolated from the patients were determined by immunohistochemistry and Western blot. Computer picture analyzing system was also ture analyzing system was also used to measure levels of HO-1 protein expression. Results HO-1 protein expression was located in the cytoplasm. The levels of O-1 protein expression in patients with acute myocardial infarction were significantly higher than those without acute myocardial infarction (P<0.01). In addition, low levels of HO-1 protein expression were observed in patients with normal coronary artery. Conclusion There is a higher expression of HO-1 in patients with acute myocardial infarction, and a lower expression in patients with normal coronary artery.
, 百拇医药
PAGE:536-539
Association between serum matrix metalloproteinase-3 concentration and the promoter 5A/6A polymorphism in patients with coronary heart disease
GAO Bo, LI Zhong-cheng.
Tianjin Tianhe Hospital, Tianjin 300050, China
Objective To investigate the association between serum matrix metalloproteinase-3 (MMP-3) concentrations and the promoter 5A/6A polymorphism in patients with coronary heart disease (CHD). Methods The study enrolled 137 CHD patients and 106 control subjects without CHD. The diagnosis of both groups were confirmed by coronary artery angiography.One hundred and thirty-seven CHD patients were divided into acute myocardial infarction(AMI) group, unstable angina pectoris(UAP) group and stable angina(SA) group according to World Health Organization criteria. Serum concentration of MMP-3 was measured by enzyme linked immunoadsorbent assay(ELISA). MMP-3 promoter gene containing the 5A/6A polymorphism was amplified by polymerase chain reaction (PCR). PCR products were digested by Tth111Ⅰand then were separated by electrophoresis on agarose gel. Results The distribution of MMP-3 genotype was not significantly different between CHD patients and controls, so was it between AMI patients and controls. Serum MMP-3 level was significantly higher in AMI group than controls, UAP group and SA group((56.815±38.932)μg/L, (39.149±24.155)μg/L, (41.640±29.180)μg/L, (33.336±20.755)μg/L； P<0.01,P<0.05, P<0.01). Serum MMP-3 levels were not significantly different among genotypes and among controls, UAP and SA groups. No significantly differences in serum MMP-3 levels were found among patients with different numbers of coronary arteries that were involved in CHD. Conclusion No marked association could be found between 5A/6A polymorphism in MMP-3 gene and risk of CHD and AMI. Higher serum level of MMP-3 is strong associated with AMI, while not with number of coronary arteries that are involved in CHD. These data suggest that MMP-3 is a useful marker for AMI, and it might play an important role in the induction of disruption of atherosclerosis plaque.
, 百拇医药
PAGE:539
Experience in treatment of brain and heart embolism in the elderly
BAO Jian-zhou, ZHOU Bao-hua , DENG Chun-fang, LIU Xin-hua
The Dongying Second Hopsital, Shandong 300250, China
PAGE:540-543
Characteristics and therapeutic strategies of nosocomial pneumonia in postoperat
ive patients with acute hypertensive intracerebral hemorrhage
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TONG Ying, ZHAN Ren-ya，SU Qun.
Department of Neurosurgery, First Affiliated Hospital, Medical College, Zhejiang University, Hangzhou 310003， Zhejiang, China
Objective To investigate the characteristics of postoperative nosocomial pneumonia in patients with acute hypertensive intracerebral hemorrhage after evacuation of hematoma and the strategies of prevention and treatment. Methods Retrospective analysis was performed on the clinical data of surgically treated patients with acute hypertensive intracerebral hemorrhage in the Department of Neurosurgery from 2000 to 2003. The patients were divided into a group who developed nosocomial pneumonia to compare with a group who did not. Sputum was cultured B and drug sensitivity of isolated bacteria was performed. Appropriate treatment measures were given according to clinical manifestations. Results In 112 post operative patients with acute hypertensive intracerebral hemorrhage, nosocomial pneumonia developed in 29 patients(25.89%), and 65.99% of microorganisms isolated from respiratory secretion was Gram-negative bacteria.The predominant bacteria were Pseudomonas aeruginosa and Staphylococcus aureus. The mortalitywas 34.48% (10/29 cases). The prognosis of patients with nosocomial pneumonia was worse than the controls(7.23%, 6/83 cases, P<0.01). Conclusion The preventive and therapeutic strategies for nosocomial pneumonia in postoperative patients with acute hypertens
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ive intracerebral hemorrhage include reduction of risk-factors, surveillance of pathogens, rational use of antibiotics, respiratory and nutrition support, and so on
PAGE: 543
A case of thyrotoxic myopathy after cardiac operation
ZHANG Qing-xiang, ZHANG Xue-mei, LIU Jing-kui, LI Zong-xiao, KONG De-ping
Mudanjiang Cardiovascular Hospital, Heilongjiang 157011, China
, 百拇医药
PAGE: 544-546
Optimal time window for minimally invasive aspiration and drainage of the hematoma in patients with intracerebral hemorrhage
LIU Li-jun, XUE Zhan-cang, YANG Guo-qing, ZHANG
Xiu-ming. The First Municipal Hospital, Shijiazhuang 050011, Hebei, China
Objective To seek the optimal time window for minimally invasive aspiration and drainage of the hematoma in patients with intracerebral hemorrhage. Methods One hundred and twenty-six patients with intracerebral hemorrhage were divided into two groups in terms of the operation time window: ultra-early stage group(within 6 hours) and early stage group (6-24 hours). European stroke scale (ESS) score and Bartherl index(BI) were used to evaluate the improvement of neurological function. Results There were no significant differences between the two groups in ESS score, complications, and past medical history on hospital admission. Also no difference existed in the volume of hematoma in different regions of the brain between the two groups, including putamen thalamus and brain lobes. However, one month after the onset, mean ESS score was 64.76±7.12 and the mean BI was 66.39±7.23 in the ultra-early stage group (non-survivors were excluded), whereas in the early stage group, they were 59.21±8.63 and 61.91±8.31 (non-survivors were excluded too), respectively (both P<0.01). Three months after the mean BI was 79.46±13.29 in the ultra-super early stage group and 72.32±11.86in the early stage group, and the difference in the two groups was significant(P<0.01). Though surgery in the ultra-early stage gave better results than that in early stage, no marked difference in mortality was found between the two groups(P>0.05). Conclusion The aspiration and drainage of the hematoma should be done as early as possible(within 6 hours of the onset) provided that the patients are fit to undergo the surgery.
, 百拇医药
PAGE: 547-551
Analysis of causes of late mortality in liver transplant recipients
PAN Cheng,Ashok Jain△, John J. Fung△.
The Department of Transplantation Surgery, Tianjin First Central Hospital, Tianjin 300192, China;△Thomas E. Starzl Transplantation Institute, University of Pittsburgh, PA, 15213, USA
Objective To evaluate the cause of late mortality in liver transplant recipients, and to study the prevention and management of these complications. Methods Two thousand nine hundred and forty patients who underwent liver transplantation at University of Pittsburgh and survived more than 1 year between February 1981 and April 1998 were included in this study. Cause of death, and other relative factors were analyzed. Results The rate of death dramatically decreased from 20.4% to 1.9% during that 10 years(1981-1991). Eight hundred and seventeen patients who survived more than 1 year had died during the follow-up period. The causes of death were malignant tumor (20.7%), cardiovascular complication (11.4%), infection (11.3%), and respiratory system complications (9.4%). Following the change in the immunosuppression protocol (1981-1986 was cyclosporin-A, 1986-1990 was OKT3, 1991-1998 was FK506), the 1-year death rate, 5-year death rate, and 10-year death rate were constantly decreased postoperatively. Patients of 3-18-year old group had the lowest mortality rate, while that of 19-60-year old group had the highest mortality rate. The patients who received liver transplantation because hepatic carcinoma or fulminant hepatic failure had the highest mortality after the operation. Mortality of the patients who received liver transplantation because of alcoholic cirrhosis increased gradually year by year. Conclusion Malignant tumor, cardiovascular complication, infection and respiratory system complications are the most common causes of late mortality after liver transplantation. Early diagnosis and treatment can improve the survival rate.
, 百拇医药
PAGE: 551
Successful rescscitation of a case with respiratory and cardiac arrest for 20 minutes
CHEN Jiang
Department of Emergency, Shanxi Spaceflight Hospital, Xi'an 710025, China
PAGE: 552-555
Clinical study on the early nutrition support in postoperative patients with critical hypertensive intracerebral hemorrhage
, 百拇医药
ZHANG Jian-jun, DONG Wei-feng, GU Shui-jun, ZHANG Jun, XUAN Hong-fei, XIE Ren-long. Department of Neurosurgery, Xiaoshan First People's Hospital, Hangzhou 311201, Zhejiang, China
Objective To investigate the clinical significance of early nutritional support for patients with critical hypertensive intracerebral hemorrhage(HICH) in a critical condition after operation, and the rationale of different methods of nutritional support. Methods One hundred and seven HICH patients after operation with Glasgow coma score(GCS) 6-8 were randomly divided into three groups: early enteral nutrition(EEN) group(38 cases);early parenteral nutrition(EPN) group(35 cases),conventional treatment controls(34 cases). They were given different nutritionalsupports 48 hours after operation. Changes in nutritional parameters and the clinical complications in three groups after treatment were observed, and the treatment effects after 3 months were compared. Results At the end of first week after operation, nutrition parameters including albmin(ALb), hemoglobin(Hgb) in EEN and EPN groups were better than those in control group(P<0.05); at the end of second week, they were differences among three groups but without statistical significance (P>0.05). The complications were higher in EPN and control groups(P<0.05 or P<0.01). The outcome was assessed 3 months after the operation in term of activity of daily life(ADL), and the result was better in EEN group than that in EPN and control groups(P<0.005). Conclusion Postoperative HICH patients in critical condition could be benifited with EEN, and complications could bereduced with improved prognosis
, 百拇医药
PAGE: 556-557
Evaluation on the therapeutic effects of two methods of stereotactic CT-guided aspiration and drainage in acute intracerebral hemorrhage
WANG Guo-ping , LI Huai-yu, REN Ming-shan , YANG Yi, SUN Bai-song, ZHU Shou-zheng , WANG Yi-xin , ZHOU Qing-chao , ZHOU Ben-xiu
Department of neurology, Anhui Municipal Hospital, An'hui 230001, China
PAGE: 558-559
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Clinical study of Nictinamide on patients with unstable Angina pectoris
ZHANG Su-rong LIU Ping CHEN Zhi-gang YUAN Yu LV Feng-hua ZHANG Yong-chun LI Hong-jun , HUANG Lu-li
Department of cariiovescular, First Affilated Hospital Xinxiang Medical College, Weihui 453100, Henan, China
PAGE: 560-561
The protective effect of zinc on myocardial ischemia/reperfusion jnjury in rabbits
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SHEN Bing-ling, QIN Yi , YAN Li-qiu
Department of Pathophysiology, Tianjin Medical University
PAGE: 561
The application of Carbostent in emergency percutaneous coronary intervention(PCI)
GUAN-wei , LIU Xin-qiao, ZHAO Chun-yan , SHAO Lei , ZHENG Xiao-wen
The Tianjin Third Hospital, 300250, Tianjin, China
, 百拇医药
PAGE: 562-563
Expression of CD44V6 In colorectal carcinoma and its clinical significance
WANG Li-ping, WU Tie-feng, WANG Chun-tian
Department of Surgery, Affiliated Hospital of Chengda Medical College, Chengde 067000, Hebei, China
PAGE: 563
Gene expression of PTEN in human glioma
XU Xin-nv, WANG Jin-huan, LI Jun-yi, LIU Hong-sheng , LU Yi, QI Jian-bin
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Key Laboratory, First Central Hospital, Tianjin 300192, China
PAGE: 564-565
Radical correction of severe teralogy of Fallot in 39 infants
WANG Jian-ming, WANG Zhen, LIU Su-ran, LU Zhi-kai , WANG Hai-ming, LIN Wei, TAO Shu-guang
Department of Cardiac surgery, Children Hospital, Hebei 050031, China
PAGE: 565
, 百拇医药
Application of magnesium sulfate in peri-operative treatment of acute amniotic embolism
ZHANG Ming-tu , LI Fang, Zhu Ming, XU Duo-jia, XU JUN , DU Guang-sheng
Department of Anesthesiology Jinhua Central Hospital, Jinhua 321000, China
PAGE: 566
Application of non-invasive hemodynamic monitoring on cor pulmonale patients under mechanical ventilation
, 百拇医药
WANG Bo , LU Zhong-yuan, SUN Ping
117th Hospital of PLA, Hanzhou 310013, China
PAGE: 567
The application of intraoperative autotransfusional technique in emergency operation with serious bleeding
ZHENG Xiang-de, FENG Qing, LIU Wen-hu , LI Shu-fang , WANG Xu , LI Zheng-qing Dazhou Central Hospital, Sichuan 635000, China
PAGE: 568-569
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Clinical observation of blood adsorption and hemodialysis on severe burned pastients LIU Hui , ZHAO Qing , HOU Xiu-ni
Weihaiwei People's Hospital, Weihai 264200, China
PAGE: 569
Response of brachial artery flow to vasodilatory drugs in hypertensive patients
ZHANG Tie-mei, XU Xiu-ying
Department of Caridolog Tiantan Hospital, Beijing 100050, China
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PAGE: 570-573
Inflammation and Acute Coronary Artery Syndrome
YANG Shen-li , LIU Hui-liang, HE Zuo-yun
Department of cardiology, The General Hospital of the people's Armed Police of Beijing 100039, China
PAGE: 573
The Fifty Examples’ soved Feeding of Breathing And Heart-beating Stopping
YANG Xiu-hui, ZHENG Fu-xia, LIU Hui-jie
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Luohe Central Hospital, Henan 462000, China
PAGE: 574-576
Advance in treatment of nervous system disease with neural stem cells
ZHANG Zhi-ming , ZHAO Jing, ZHU Zhao-lin
Department of Neurosurgery, Tianhe Hospital, Tianjin 300050, China, 百拇医药