单克隆抗体SC3A在胃癌及癌前病变的表达意义
抗体，单克隆,代谢胃肿瘤,免疫学,项目负责人,SignificanceofmonoclonalantibodySC3Aexpressioningastriccarcinomaandprecancerouslesion,Abstract,AIM,METHODS,RESULTS,CONCLUSION,Subjectheadings,摘,要,目的,方法,结果,结论,主题
1安徽医科大学病理学教研室 安徽省合肥市 2300322沈阳军区总医院医学实验科 辽宁省沈阳市 110015
*安徽省教委科研基金资助项目
吴继锋，男，1957-08-24生，安徽省合肥市人，汉族. 1983年安徽医科大学医学系毕业，1986年安徽医科大学病理解剖学专业硕士毕业，副教授，主要从事胃癌的病理研究，发表论文30篇，获省部级科技进步奖3项.
项目负责人 吴继锋，安徽省合肥市梅山路21号.
Tel: 0551-2816602-2090.收搞日期 1996-10-10 接受日期 1996-12-02
Significance of monoclonal antibody SC3A expression in gastric carcinoma and precancerous lesion
Ji-Feng Wu, Yu-Lin Song, Guang-Lin Yang, Yu-Ming Dong, Dao-Bing Wang and Min-Pei Liu
Department of Pathology, Anhui Medical University, Hefei 230032, Anhui Province, China
Abstract
AIM To study the significance of monoclonal antibody SC3A ex pression in gastric carcinoma and precancerous lesion.
METHODS Immunohistochemical staining and mucin histochemical st aining were performed on paraffinembedded sections from gastric benign and mal ignant lesions of 101 cases.
RESULTS SC3A positive rate was 80.3% (57/71) in gastric carcin oma. The expression of SC3A was not related to classification, differentiation, metastasis and survivals. The positive rate of SC3A in cancers secreting acid mu cin (90.2%) or sulphomucin (91.3%) was higher than that in cancers without aci d mucin (20.0%) or sulphomucin (60.0%) (P<0.01). The positive rate of su lphomucin was higher in intestinal metaplasia with cancer (88.9%) than that of intestinal metaplasia with benign lesion (35.3%) (P<0.01). The positive r ate of SC3A with sulphomucin in intestinal metaplasia (60.9%) was higher than t hat without sulphomucin (31.3%) (P<0.05). ......
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