血管阻塞在乙型肝炎纤维化中的作用
肝静脉闭塞性疾病,并发症;肝炎，乙型,并发症;肝硬变,病因学,作者简介,VascularobstructioninpathogenesisofhepatitisBfibrosis,Subjectheadings,Abstract,AIM,METHODS,RESULTS,CONCLUSION,主题词,摘要,目的,方法,结果,结论,1材料和
作者简介 严家春，男，1941-06-01生，安徽省定远县人，汉族. 1972年第七军医大学医资班毕业，解放军123医院肝病研究中心，主任医师，教授，主要从事肝病的病理学研究，《实用肝脏病杂志》编委，参编《现代传染病文集》，发表论文100篇，获军队科技进步奖11项[安徽省蚌埠市燕山路1052号.电话(0552)4088701].(收稿 1997-02-20 修回 1997-04-01)Vascular obstruction in pathogenesis of hepatitis B fibrosis
YAN Jia-Chun, LIU Jian-Hu and MA Yong
Department of Liver Diseases, Chinese PLA 123 Hospital Bengbu 233015, Anhui Province, China
Subject headings hepatic veno-occulusive disease/complications; hepatitis B/complications; liver cirrhosis/etiology
Abstract
AIM To study the relationship between vascular obstructive lesions and fibrosis of hepatitis B.
METHODS Liver biopsies from 1079 patients with hepatitis B were studied with HE, histochemical and immunochemical stain.
RESULTS Hepatic fibrosis indexes were increased with the degrees of mild (2.94±1.56), moderate (5.48±1.30) and severe (6.63±1.97) in the liver vascular obstruction (P<0.01). In the group of mild vascular obstruction, no fibrous band was found in 61%, and narrow fibrous bands accounted for 39%; while in the moderate group, broad and narrow fibrous bands covered 51% and 49%, respectively; and 7.8% and 92.2% (P<0.01) in the severe group. Histopathological distribution of hepatic fibrosis varied from one region of the liver to another and accompanied by vascular occlusion. The newly formed fibrous bands were composed of capillaries. Bridging fibrosis was linked up by newly formed capillaries. The formation of fibrous septa in cirrhosis was in accordance with vascular lesions. ......
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